Validity of the finger tapping test in Parkinson's disease, elderly and young healthy subjects: is there a role for central fatigue?

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Pablo AriasJavier Cudeiro

Abstract

The main goal of this work is to evaluate the validity of the finger tapping test (FT) to detect alterations in rhythm formation. We use FT to study the alterations in motor rhythm in three different groups: Parkinson's patients, elderly healthy controls, and young healthy control subjects (HY). The test was performed in COMFORT and FAST tapping modes and repeated on two different days. For the variables analyzed (frequency and variability) both modes were repeatable in all groups. Also, intra-class correlation coefficients showed excellent levels of consistency between days. The test clearly differentiated the groups in both FAST and COMFORT modes. However, when fatigue was analyzed, a decrease in the tapping frequency was observed in HY during the FAST mode only. The amplitude of motor evoked potentials (MEPs) induced by transcranial magnetic stimulation (TMS) was early-potentiated but not delayed-depressed, both for COMFORT and FAST modes. This suggests that fatigue was not of cortico-spinal origin. Other forms of central fatigue are discussed. FT at FAST mode is not a valid test to detect differences in rhythm formation across the groups studied; fatigue is a confounding variable in some groups if the test is performed as f...Continue Reading

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Citations

May 20, 2015·Journal of Motor Behavior·Leyla AydinNimet Unay Gundogan
Jun 20, 2015·Parkinson's Disease·Wing Lok AuLouis Chew Seng Tan
May 6, 2016·Scientific Reports·Motoyasu HonmaMitsuru Kawamura
May 18, 2016·Parkinsonism & Related Disorders·Evžen RůžičkaZoltán Szabó
Jun 28, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Milica Djurić-JovičićVladimir S Kostić
Feb 27, 2017·IEEE Transactions on Bio-medical Engineering·Teresa Arroyo-GallegoLuca Giancardo
Sep 11, 2018·Journal of Motor Behavior·Maria RönnefarthStephan A Brandt
Sep 17, 2019·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·Elisa GervasoniMarco Bove
Jul 1, 2017·Frontiers in Human Neuroscience·Giuseppe CosentinoFilippo Brighina
May 1, 2018·Fatigue : Biomedicine, Health & Behavior·Roland StaudMichael E Robinson
Jan 29, 2019·Frontiers in Applied Mathematics and Statistics·Corinne A JonesTimothy M McCulloch
May 16, 2019·The American Journal of Hospice & Palliative Care·Carlos FernandezMellar Davis
Jan 12, 2021·Movement Disorders Clinical Practice·Gilles NaeijeXavier De Tiège
Sep 26, 2020·Dysphagia·James C BordersMichelle S Troche

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