Validity of the Liverpool Adverse Events Profile as a Screening Tool for Detecting Comorbid Depression or Anxiety Disorder in People with Epilepsy

Journal of Epilepsy Research
Oh-Young Kwon, Sung-Pa Park

Abstract

The Liverpool adverse events profile (LAEP) is useful for detecting and monitoring the adverse effects of antiepileptic drugs (AEDs) and contains items related to symptoms of depression or anxiety. This study evaluated the usefulness of the LAEP for detecting comorbid depression or anxiety disorder in people with epilepsy (PWE). PWE, aged from 18 to 70 years and who took AEDs for at least 1 year, were included. They completed the Korean version of the LAEP (K-LAEP) to detect the adverse effects of AEDs and the mini international neuropsychiatric interview-plus version 5.0.0 (MINI) to identify major depressive disorder (MDD) and generalized anxiety disorder (GAD). We validated the K-LAEP as a screening tool for coexisting MDD or GAD in PWE. Receiver operating character (ROC) curve analyses were used to measure the appropriateness of cutoff scores for the total and item K-LAEP scores for detecting MDD or GAD. The study enrolled 150 PWE. According to the MINI, 30 PWE (20.0%) had MDD and 26 (17.3%) had GAD. Cronbach's α coefficient of the K-LAEP was 0.939. For the total K-LAEP score, cutoff scores of 40 and 43 could detect MDD and GAD, respectively. For the K-LAEP item score, a cutoff of five could detect MDD or GAD. The K-LAEP is ...Continue Reading

References

Mar 1, 1997·Epilepsia·G A BakerD Monnet
Nov 1, 2003·Epilepsy & Behavior : E&B·Jana E JonesKimford J Meador
Mar 22, 2006·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Yon Mi SungYoung Soo Do
Jul 14, 2007·Epilepsy Research·Nikolas HitirisMartin J Brodie
Jul 25, 2012·Seizure : the Journal of the British Epilepsy Association·Gerardo Maria de Araújo FilhoRicardo Silva Centeno
Jul 27, 2012·Lancet Neurology·Piero Perucca, Frank G Gilliam
May 7, 2014·Epilepsy & Behavior : E&B·Jong-Geun SeoSung-Pa Park
Jul 11, 2014·Seizure : the Journal of the British Epilepsy Association·Se-Jin LeeSung-Pa Park
Jan 30, 2015·Journal of Clinical Neurology·Jong-Geun SeoSung-Pa Park
Apr 15, 2015·Epilepsy & Behavior : E&B·Soo-Kyoung KimOh-Young Kwon

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Citations

Dec 25, 2019·Seizure : the Journal of the British Epilepsy Association·Tae-Won YangOh-Young Kwon
Dec 29, 2020·Epilepsy & Behavior : E&B·Yew Li DangCharles B Malpas
Apr 10, 2021·Journal of Clinical Neurology·Elaine LuMartha Sajatovic

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