Validity, Usefulness and Cost of RETeval System for Diabetic Retinopathy Screening

Translational Vision Science & Technology
Humoud Al-OtaibiIgor Kozak

Abstract

We studied the validity, usefulness, and relative cost to detect diabetic retinopathy (DR) and sight-threatening DR (STDR) by using a hand-held electrophysiologic tool compared to digital fundus photography. Patients with diabetes attending the screening unit of King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia were evaluated by "RETeval", Amsler grid, and digital dilated fundus photography. Fundus images were evaluated by a retina specialist to determine grade of DR. The sensitivity and specificity of STDR and DR screening compared to photography were calculated, as well as "RETeval" combined with Amsler grid testing. The area under the curve (AUC) of "RETeval" screening outcome was calculated. We analyzed data of 400 diabetic patients. The prevalence of DR of any grade was 48.8% (95% confidence interval [CI], 43.9-53.7) while the prevalence of STDR was 27% (95% CI, 22.6-31.4). The outcome of RETeval test was "fail" (based on 20 μV or more amplitude of electrophysiologic spikes) in 351 (87.8%; 95% CI, 84.5-91.0) eyes. The sensitivity of the device was 95.4% and the specificity was 17.5%. Thus, the sensitivity of sequential testing with RETeval and Amsler grid test was 30.1% and the specificity was 80.1%. The AUCs for S...Continue Reading

Citations

Dec 6, 2017·Clinical & Experimental Ophthalmology·Heather G MackRc Andrew Symons
May 22, 2018·Expert Review of Pharmacoeconomics & Outcomes Research·Islam EljilanyZaheer-Ud-Din Babar
Oct 26, 2018·Documenta Ophthalmologica. Advances in Ophthalmology·Henry LiuCarol Westall
Oct 20, 2018·Documenta Ophthalmologica. Advances in Ophthalmology·Mehmet Fatih Kağan DeğirmenciEmin Özmert
Mar 4, 2019·Documenta Ophthalmologica. Advances in Ophthalmology·Xiang JiCarol A Westall
Jan 9, 2019·Translational Vision Science & Technology·Jessica TangJonathan G Crowston
Sep 11, 2020·Translational Vision Science & Technology·Mitchell G BrigellC Quentin Davis
Oct 30, 2020·Clinical Ophthalmology·Elizabeth Pearce, Sobha Sivaprasad

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Software Mentioned

RET
Statistical Package for Social Studies ( SPSS

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