Valinomycin affects the morphology of Candida albicans

The Journal of Antibiotics
Hiroshi WatanabeHiroshi Ooshima

Abstract

Microbial metabolites were screened for inhibitors of hyphal growth in Candida albicans. Inhibitory activity was found among metabolites of a culture of an actinomycete, which had been isolated from soil. The active substance inhibited hyphal growth and induced growth as a chain of yeast cells under hyphal growth induction conditions. The active substance was purified and analyzed with 1H-NMR, 13C-NMR and mass spectra. The substance was identified as valinomycin, and commercial valinomycin inhibited hyphal growth as effectively as the purified metabolite. The effective concentration was from 0.49 to 62.5 microg/ml. Valinomycin also inhibited hyphal growth in other dimorphic fungi, Candida tropicalis and Aureobasidium pullulans. These results suggest that valinomycin may be a useful tool for understanding the morphological transition of dimorphic fungi.

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Citations

Sep 13, 2011·Organic Letters·Cosimo AnnesePaul G Williard
Aug 4, 2006·The Journal of Antibiotics·Hiroshi WatanabeHiroshi Ooshima
Jan 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ilka SchoenianDieter Spiteller
Nov 26, 2009·Mycologia·Ralph A Slepecky, William T Starmer

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