Valorization of onion solid waste and their flavonols for assessment of cytotoxicity, enzyme inhibitory and antioxidant activities

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Arti Shivraj NileKavita Sharma

Abstract

Onion (Allium cepa L.) is rich with flavonols which perceived benefits to human health. Flavonols like quercetin and quercetin glycosides from onion solid waste (OSW) have been extracted and tested against enzymes of clinical importance in Alzheimer's disease and diabetes and be shown to have cytotoxic and antioxidant effects. A simple high-performance liquid chromatography-diode array detector method using a Zorbax Eclipse XDB C18 column was developed to separate quercetin-3, 4'-O-diglucoside, quercetin-4'-O-monoglucoside, and quercetin from OSW. These compounds were identified using infrared, ultra-violet, 1H, and 13C nuclear magnetic resonance spectroscopic techniques. The OSW solvent fractions and flavonols showed significant antioxidant activities using DPPH (1, 1-diphenyl-2-picrylhydrazyl), FRAP (ferric reducing antioxidant power), and ABTS (2,2'-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid) radical scavenging assays. The samples exhibited significant in vitro anti-cholinesterase activity with strong antidiabetic effects. OSW extracted with methanol and ethanol showed greater in vitro anti-cholinesterase and hypoglycemic effects than QDG, QMG, and Q possibly due to interactions between multiple compounds and/or comple...Continue Reading

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Citations

Sep 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nunzio Antonio CacciolaAlessandra Morana
Apr 25, 2020·International Journal of Molecular Sciences·Mariana Gois Ruivo da SilvaLea Pogačnik
Sep 24, 2020·Antioxidants·Damini KothariSoo-Ki Kim
Jun 6, 2019·Topics in Current Chemistry·Aleksandra PałaszBartłomiej Bazan
Sep 25, 2019·International Journal of Molecular Sciences·Alberto Jorge Oliveira LopesMaria Nilce de Sousa Ribeiro
Nov 22, 2019·Anti-cancer Agents in Medicinal Chemistry·Rumana AhmadArvind K Srivastava
Jun 12, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Arti NileJae-Wook Oh
Jul 29, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Marina FidelisDaniel Granato

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