Valproate and amitriptyline exert common and divergent influences on global and gene promoter-specific chromatin modifications in rat primary astrocytes.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Tatjana PerisicJürgen Zschocke

Abstract

Aberrant biochemical processes in the brain frequently go along with subtle shifts of the cellular epigenetic profile that might support the pathogenic progression of psychiatric disorders. Although recent reports have implied the ability of certain antidepressants and mood stabilizers to modulate epigenetic parameters, studies comparing the actions of these compounds under the same conditions are lacking. In this study, we screened amitriptyline (AMI), venlafaxine, citalopram, as well as valproic acid (VPA), carbamazepine, and lamotrigine for their potential actions on global and local epigenetic modifications in rat primary astrocytes. Among all drugs, VPA exposure evoked the strongest global chromatin modifications, including histone H3/H4 hyperacetylation, 2MeH3K9 hypomethylation, and DNA demethylation, as determined by western blot and luminometric methylation analysis, respectively. CpG demethylation occurred independently of DNA methyltransferase (DNMT) suppression. Strikingly, AMI also induced slight cytosine demethylation, paralleled by the reduction in DNMT enzymatic activity, without affecting the global histone acetylation status. Locally, VPA-induced chromatin modifications were reflected at the glutamate transport...Continue Reading

References

Aug 1, 1996·Developmental Biology·B P BrunkC P Emerson
Jul 23, 1998·Clinical and Experimental Pharmacology & Physiology·R J Vandenberg
Dec 22, 1998·Histochemistry and Cell Biology·B FrankeJ Engele
May 14, 1999·Current Opinion in Genetics & Development·H H Ng, A Bird
May 20, 1999·Biological Psychiatry·G RajkowskaC A Stockmeier
Apr 20, 2001·Neurochemistry International·M InazuT Matsumiya
Dec 1, 2001·The Journal of Biological Chemistry·Amaris R Guardiola, Tso-Pang Yao
Jun 18, 2002·Current Opinion in Cell Biology·Monika Lachner, Thomas Jenuwein
Dec 18, 2002·Journal of Neurochemistry·Masato InazuTeruhiko Matsumiya
Apr 25, 2003·Nucleic Acids Research·François FuksTony Kouzarides
May 16, 2003·The Journal of Biological Chemistry·Nancy DetichMoshe Szyf
Jun 5, 2003·Journal of Affective Disorders·Hari ManevRadmila Manev
Sep 27, 2003·Epilepsia·Antonino Pavone, Venera Cardile
Nov 6, 2003·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Arturas Petronis
Nov 25, 2003·The New England Journal of Medicine·James G Herman, Stephen B Baylin
Feb 12, 2004·Cancer Research·Nadia GurvichPeter S Klein
Feb 20, 2004·Nucleic Acids Research·Allen S YangJean-Pierre J Issa
May 22, 2004·Nature Reviews. Genetics·Melissa J Fazzari, John M Greally
Jun 29, 2004·Nature Neuroscience·Ian C G WeaverMichael J Meaney
Jul 15, 2004·Glia·Carola G Schipke, Helmut Kettenmann
Jul 28, 2004·Molecular Psychiatry·D C Javitt
Apr 27, 2005·Life Sciences·Andreas S BeutlerMartin J Walsh
Jan 6, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Boldizsár CzéhEberhard Fuchs
Apr 21, 2006·Experimental Cell Research·Mohsen KarimiTomas J Ekström
May 4, 2006·Molecular Pharmacology·Suzanne CasselJean Zwiller
Jun 22, 2006·Current Topics in Medicinal Chemistry·Arne Schousboe, Helle S Waagepetersen
Aug 29, 2006·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Ana C D'Alessio, Moshe Szyf
Sep 2, 2006·Biological Psychiatry·Frederick A SchroederSchahram Akbarian
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·E DongE Costa
Apr 11, 2007·Molecular Psychiatry·J Mill, A Petronis
Jun 19, 2007·Biological Psychiatry·Kenji HashimotoMasaomi Iyo
Oct 19, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hsien-Sung HuangSchahram Akbarian

❮ Previous
Next ❯

Citations

Nov 19, 2013·Pflügers Archiv : European journal of physiology·Christof GrewerThomas Rauen
Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Mary E Hamby, Michael V Sofroniew
Jan 27, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Irina A IonescuUlrike Schmidt
Apr 22, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jürgen ZschockeTheo Rein
Dec 20, 2011·Bioinformatics·Wilson Wen Bin GohLimsoon Wong
Aug 12, 2010·Behavioural Pharmacology·Livia PasqualiFrancesco Fornai
Nov 30, 2011·Epigenomics·Yannick MengerDietmar Spengler
Dec 21, 2012·Expert Opinion on Investigational Drugs·Daniela TarditoMaurizio Popoli
Jun 7, 2012·Expert Opinion on Investigational Drugs·Sharon BerendsenPierre Robe
Jan 23, 2016·Epigenomics·Lotte C HoutepenMarco P M Boks
Feb 24, 2010·Journal of Neuroimmunology·Rongtai WeiYu-Ying Tu
Sep 12, 2013·The Journal of Pain : Official Journal of the American Pain Society·Masaru YoshizumiKen-ichiro Hayashida
Jul 19, 2013·Pharmacotherapy·Julio D Duarte
Oct 2, 2014·Journal of Neurochemistry·Georgi Gegelashvili, Ole J Bjerrum
Mar 26, 2016·Expert Review of Neurotherapeutics·Liang PengAlexei Verkhratsky
Jun 3, 2015·Cellular and Molecular Life Sciences : CMLS·Kou TakahashiChien-Liang Glenn Lin
Sep 6, 2014·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Myoung Suk SeoBrian Dean
Aug 14, 2012·The Biochemical Journal·Nicole ZimmermannTheo Rein
Dec 31, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Marco P BoksRoel A Ophoff
Mar 16, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Alicia K SmithPatricia A Brennan
May 16, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Lucio TremolizzoCarlo Ferrarese
May 20, 2011·Journal of Psychiatric Research·Fumihiro HiguchiYoshifumi Watanabe
May 23, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Boldizsár Czéh, Barbara Di Benedetto
Oct 28, 2015·Developmental Neurobiology·Hee Jae LeeEmanuel DiCicco-Bloom
Jun 23, 2016·Neuroscience and Biobehavioral Reviews·Gabriel R FriesJoao Quevedo
Oct 25, 2016·Journal of Affective Disorders·Angela C BustamanteMonica Uddin
Aug 17, 2016·International Journal of Molecular Sciences·Kathleen SaavedraLuis A Salazar
Sep 7, 2016·Drug Development Research·Seher Karsli-Ceppioglu
Apr 13, 2017·Development and Psychopathology·Jennifer Blaze, Tania L Roth
May 27, 2017·Nature Reviews. Neurology·Ellen NiederbergerGerd Geisslinger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.