Valproate and lamotrigine in pediatric patients with refractory epilepsy: after the first year

Pediatric Neurology
Sigride Thome-Souza, Kette D Valente

Abstract

The combination of lamotrigine and valproate/divalproex sodium has been shown to be effective in the treatment of refractory epilepsy. This study aims to evaluate the pharmacologic properties of using this combination in a pediatric population refractory to antiepileptic drugs, with an extended follow-up. We studied a group of 51 patients, ranging from 4 to 16 years of age. Sixteen patients (31.4%) had generalized epilepsy and 35 (69.6%) had focal epilepsy. The combination was effective in 39 patients (76.5%) in the first year of follow-up and in 36 patients (70.6%) in the second year, with a reduction in drop attacks observed in 22 (88.5%). Adverse effects included rash, leading to discontinuation in four patients (7.8%). Slower introduction of lamotrigine minimizes adverse effects, thereby improving quality of life and adherence to treatment. In addition, therapeutic efficacy is maintained with lower doses of lamotrigine, even after the first year of treatment.

References

Dec 1, 1995·The Journal of Pediatrics·F M BesagG Hosking
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Mar 16, 2001·Expert Opinion on Pharmacotherapy·P H McCabe
Aug 31, 2001·Archives of Neurology·P H McCabeN C Michel
Jul 25, 2003·Pediatric Neurology·Sigride Thomé-SouzaKette D Valente
Apr 13, 2006·Paediatric Drugs·Renzo Guerrini
May 2, 2006·Epilepsy & Behavior : E&B·Ho-Won LeeSung-Pa Park
Sep 25, 2008·Arquivos de neuro-psiquiatria·Karen P GrisottoLúcia H C Santos
Mar 9, 2010·Thérapie·Olivier TributUNKNOWN le groupe Suivi Thérapeutique Pharmacologique de la Société Française de Pharmacologie et de Thérapeutique
Jun 19, 2012·Pediatric Neurology·Sigride Thome-SouzaKette D Valente
Mar 19, 2014·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yueh-Ching ChouYuan-Hwa Chou

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Citations

Jun 14, 2015·BMJ Open·Oluwaseun EgunsolaHelen M Sammons

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