PMID: 2498075May 1, 1989Paper

Valproate competes with palmitate for binding to serum albumin

Epilepsia
H VorumR Brodersen

Abstract

Addition of sodium valproate (VPA) to a buffered solution of human serum albumin (HSA) or to serum reduces binding affinity for palmitate. A maximal pharmacologic VPA concentration, 700 microM, added to a 300-microM albumin solution, reduces the reserve albumin concentration for binding of palmitate by a factor of 0.64. One possible site model explaining these findings may be that VPA competes strongly with one among three palmitate molecules, bound to albumin with high affinity, and induces a weaker displacement of a second palmitate.

References

Oct 14, 1977·European Journal of Clinical Pharmacology·R GuglerH U Schulz
Apr 1, 1979·Archives of Biochemistry and Biophysics·I M Klotz, D L Hunston
Feb 1, 1988·Archives of Biochemistry and Biophysics·H SatoR Brodersen
May 16, 1988·European Journal of Biochemistry·R BrodersenS Andersen
Jun 1, 1974·The Journal of Clinical Investigation·R J LewisW Schary
Jan 1, 1983·Developmental Pharmacology and Therapeutics·R BrodersenL Stern
Aug 1, 1984·Acta Neurologica Scandinavica·H DinesenM Dam
Aug 29, 1981·British Medical Journal·J Egger, E M Brett

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Citations

Apr 10, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·C BertucciV Cavrini
Apr 1, 1997·Seizure : the Journal of the British Epilepsy Association·D EasterC Verity

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