Valproate impact and sex-dependent seizure remission in patients with idiopathic generalized epilepsy

Journal of the Neurological Sciences
Emanuele Cerulli IrelliCarlo Di Bonaventura

Abstract

Idiopathic Generalized Epilepsy (IGE) management has become increasingly challenging due to the restricted use of Valproate (VPA) in females. The aim of the study was to assess possible differences in terms of seizure outcome between men and women suffering from IGE. A cohort of IGE patients (age range: 13-50 years) followed from 1980 to 2018 were included. Their medical history was retrospectively reviewed to investigate possible factors influencing seizure outcome. Seizure Remission (SR) was defined as the absence of any seizure type over 18 months prior to the last medical observation. The primary outcome was to evaluate sex differences in terms of SR at last observation. A multivariable logistic regression model was elaborated using SR as dependent variable. Three-hundred and sixty patients were included, 204 (56.7%) of whom were women. The median age at the end of follow-up was 30. At last medical observation, fewer women were receiving VPA compared with men (females 39.7% vs males 79.5%, p < .001). Overall SR was 70.6%. SR was significantly different according to sex (females 62.3% vs males 81.4%, p < .001). Multivariable logistic regression model showed that female sex (Odds Ratios [OR] = 0.52, 95% Confidence Interval [C...Continue Reading

Citations

Feb 2, 2021·Seizure : the Journal of the British Epilepsy Association·Loretta GiulianoBarbara Mostacci
Apr 24, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Dilara Mermi DibekBarış Baklan
May 7, 2021·Epilepsy & Behavior : E&B·Arife Çimen AtalarBetül Baykan
Jul 28, 2021·Acta Neurologica Scandinavica·Emanuele Cerulli IrelliCarlo Di Bonaventura
Nov 19, 2021·Acta Neurologica Scandinavica·Emanuele Cerulli IrelliCarlo Di Bonaventura

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