Valproate-induced encephalopathy with predominant pancerebellar syndrome.

Indian Journal of Pharmacology
Rajesh Verma, Prakash Kori

Abstract

Valproate-induced hyperammonemic encephalopathy is a rare event clinically characterized by impaired sensorium, vomiting, headache, seizures and focal neurological deficits. The pathogenesis of this dreadful complication is not well understood, although hyperammonemia has been implicated in causation of encephalopathy. In this submission, we have highlighted a case of valproate-induced encephalopathy who presented mainly with bilateral cerebellar features and generalized slowing on electroencephalogram. High index of suspicion of valproate-induced hyperammonemic encephalopathy is required if diffuse ataxia is present as it is a potentially reversible clinical disorder.

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Citations

Dec 15, 2015·Journal of Clinical Psychopharmacology·Ravi Sivaperumal RamasamyMark Lerman
Feb 15, 2014·Asia Pacific Allergy·Evy YunihastutiTeguh Harjono Karjadi
May 31, 2019·Current Opinion in Allergy and Clinical Immunology·Jonny PeterRannakoe J Lehloenya
Jul 31, 2020·Digestive Diseases and Sciences·Bilal TokaErkan Parlak

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