Valproate, lamotrigine, and insulin-mediated risks in women with epilepsy

Annals of Neurology
J I IsojärviJ S Tapanainen

Abstract

We recently reported the frequent occurrence of polycystic ovaries and hyperandrogenism associated with weight gain and hyperinsulinemia in women taking valproate for epilepsy. The purpose of this study was to evaluate the risks related to valproate-induced hyperinsulinemia and their reversibility after discontinuing the medication. Sixteen women with valproate-related polycystic ovaries or hyperandrogenism participated in the study. Vaginal ultrasonography was performed, and endocrine and lipid parameters were measured. Thereafter, lamotrigine was substituted for valproate and the patients were observed for 12 months. Twenty-four healthy age-matched women served as control subjects. Twelve women completed the 12-month follow-up. While still on valproate they had centripetal obesity with associated hyperinsulinemia and unfavorable serum lipid profiles. The body-mass index and fasting serum insulin and testosterone concentrations decreased during the first year after replacing valproate with lamotrigine whereas the HDL-cholesterol/total cholesterol ratios increased from 0.17 +/- 0.06 to 0.26 +/- 0.05. The total number of polycystic ovaries in these women decreased from 20 during valproate medication to 11 one year after replacin...Continue Reading

References

Sep 26, 1991·The New England Journal of Medicine·D E Moller, J S Flier
Aug 1, 1990·Fertility and Sterility·R A WildM Bartholomew
Aug 1, 1984·Acta Neurologica Scandinavica·H DinesenM Dam
Aug 29, 1981·British Medical Journal·J Egger, E M Brett
Jun 1, 1995·Current Opinion in Obstetrics & Gynecology·H S Jacobs
Sep 28, 1995·The New England Journal of Medicine·S Franks
Dec 1, 1993·Clinical Endocrinology·G S Conway, H S Jacobs
Jul 20, 1993·Biochemical Pharmacology·S Ponchaut, K Veitch
Nov 4, 1993·The New England Journal of Medicine·J I IsojärviV V Myllylä
May 1, 1996·Annals of Neurology·J I IsojärviV V Myllylä

❮ Previous
Next ❯

Citations

Apr 22, 1999·Annals of Neurology·L K VainionpääJ I Isojärvi
Mar 29, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Aman BadhwarFrederick Andermann
Mar 9, 2006·Der Nervenarzt·B Schmitz, L Bergmann
Dec 25, 2004·European Journal of Clinical Pharmacology·P D KnoesterY A Hekster
Dec 21, 2000·Current Psychiatry Reports·G A Carlson, S E Meyer
May 16, 2013·CNS Drugs·Athanasios Gaitatzis, Josemir W Sander
Oct 16, 2002·Journal of Psychosomatic Research·Dan W Haupt, John W Newcomer
Jan 29, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Fisun AkdenizSimavi Vahip
Jun 6, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Diane C Lagace, Mark W Nachtigal
Jul 29, 2000·Pediatric Neurology·E Demir, S Aysun
Jul 20, 2002·Reproductive Toxicology·Erik TaubøllEwa L Gregoraszczuk
Oct 29, 2002·Reproductive Toxicology·Line Sveberg RøsteLeif Gjerstad
Jul 3, 2003·Epilepsy Research·Martha J MorrellJohn Messenheimer
Aug 29, 2001·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·C J GlueckL Sieve-Smith
Nov 25, 2003·Seizure : the Journal of the British Epilepsy Association·Line Sveberg RøsteLeif Gjerstad
May 25, 2002·Epilepsia·Virpi PylvänenJouko I T Isojärvi
Jun 26, 2003·Epilepsia·Martha J Morrell
Jul 11, 2008·The New England Journal of Medicine·Jacqueline A French, Timothy A Pedley
Dec 17, 2008·The Australian and New Zealand Journal of Psychiatry·Jane L ElmslieRussell S Scott
Nov 13, 2002·Journal of Child and Adolescent Psychopharmacology·Ema Saito, Vivian Kafantaris
May 7, 1999·Journal of the American Academy of Child and Adolescent Psychiatry·N D RyanJ M Perel
Feb 24, 2005·Journal of the American Academy of Child and Adolescent Psychiatry·Robert A KowatchUNKNOWN Child Psychiatric Workgroup on Bipolar Disorder
Jun 23, 2005·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Deborah N BlackCorinne A Pelletier
Apr 13, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K PhabphalA Geater
Oct 26, 1999·Epilepsia·F Matsuo
Jul 8, 2000·Epilepsia·R S Greenwood
Sep 20, 2006·Epilepsia·Virpi PylvänenJouko Isojärvi
Aug 18, 2009·Epilepsia·Alberto VerrottiFrancesco Chiarelli
Jan 6, 2011·Epilepsia·Alberto VerrottiFrancesco Chiarelli
Aug 2, 2005·Epilepsy Currents·Andres M Kanner
Jul 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·J BauerC E Elger
May 10, 2005·Postgraduate Medical Journal·M D O'Brien, S K Gilmour-White

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.