PMID: 2507956Oct 1, 1989Paper

Valproate prevents the recurrence of absence status

Neurology
S F BerkovicP F Bladin

Abstract

We assessed the value of valproate in the prevention of recurrent attacks of absence status in 25 patients. Eighteen patients had primary generalized epilepsy with a mean frequency of attacks of absence status of 5.7 per year. After a mean follow-up period of 4.4 years, the attack frequency was reduced to 0.6 per year (p less than 0.0005); 14 patients had no recurrence, 3 had rare attacks with noncompliance, and 1 had an incomplete response probably due to gastrointestinal intolerance. Patients with evidence of generalized cerebral damage (n = 2) or with EEG evidence of focalization (n = 5) did not respond as favorably. Valproate is the drug of choice for the prevention of recurrence of absence status. Moreover, the response can be predicted on the basis of the electroclinical subtype of absence status.

Citations

Jun 1, 1995·Italian Journal of Neurological Sciences·C TiacciA Ferroni
Nov 30, 2000·Current Treatment Options in Neurology·K Murphy, N Delanty
Jan 1, 1995·Epilepsia·B F Bourgeois
Aug 1, 1995·Archives of Disease in Childhood·G StoresA Hoshika
Apr 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·G D Jackson, S F Berkovic
Jul 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·O C CockerellS D Shorvon
Jun 8, 2001·Paediatric Drugs·C P Panayiotopoulos
Mar 25, 2014·Epilepsy Research and Treatment·Leonilda BiloRoberta Meo
Feb 19, 2009·Revue neurologique·P Thomas, P Gelisse
Nov 9, 2005·Expert Review of Neurotherapeutics·Michael KoutroumanidisStella Veronica Tan
Apr 1, 1994·Annals of Emergency Medicine·A Jagoda
Mar 17, 2007·Lancet Neurology·Hartmut Meierkord, Martin Holtkamp
Aug 27, 2005·The Psychiatric Clinics of North America·Silvana Riggio
Jun 22, 2002·Seizure : the Journal of the British Epilepsy Association·Betül BaykanMefkure Eraksoy
Mar 4, 1999·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R G Corkill, R J Hardie
Oct 1, 1994·Journal of Child Neurology·J M Pellock

❮ Previous
Next ❯

Related Concepts

Related Feeds

Absence Epilepsy

Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Discover the latest research on absence epilepsies here.

© 2022 Meta ULC. All rights reserved