PMID: 6401356Jan 1, 1983Paper

Valproic acid and intractable seizures in severely brain-damaged patients

Neurology
S Chayasirisobhon, M Russell

Abstract

We treated 52 mentally retarded patients with intractable seizures by adding valproic acid (VPA) to other drug regimens. Sixty-one percent improved clinically. VPA significantly reduced the frequency of generalized tonic-clonic seizures, generalized myoclonus, absence and atonic seizures. There was a significant correlation between clinical improvement and reduction of EEG paroxysmal activity.

Citations

Jul 1, 1992·Muscle & Nerve·L SantoroG Caruso
Jun 5, 1999·International Journal of Clinical & Laboratory Research·A VerrottiF Chiarelli
Jan 1, 1984·Epilepsia·O Dulac, M Arthuis
Jan 1, 1986·Brain & Development·O DulacM Arthuis
Oct 1, 1993·Journal of Child Neurology·D L Hurst
Oct 1, 1985·Journal of Neurochemistry·M E SmithT J Sims
Jun 1, 1987·Developmental Medicine and Child Neurology·E BeghiE Manghi
Aug 1, 1988·Developmental Medicine and Child Neurology·J Aicardi

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