PMID: 377134Jun 1, 1979Paper

Valproic acid and plasma levels of phenytoin

Neurology
J BruniB Barbour

Abstract

Eight patients were treated concurrently with a constant dose of phenytoin and valproic acid for 1 year. During initial therapy with valproic acid, total plasma phenytoin levels decreased. The interaction was transient and was not observed at the end of 1 year. Total plasma phenytoin levels returned to pre-valproic-acid levels in seven patients.

Citations

Jan 12, 1999·British Journal of Pharmacology·O E Della PaschoaM Danhof
Sep 1, 1989·The Japanese Journal of Psychiatry and Neurology·T KugohK Kashihara
Feb 1, 1981·Epilepsia·K M KochR H Levy
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Nov 1, 1979·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J BruniB J Wilder
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Jul 23, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Eyal SobolMeir Bialer
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May 8, 2021·Frontiers in Cell and Developmental Biology·Chiara ParodiValentina Massa

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