PMID: 6985722Jan 1, 1980Paper

Valproic acid and plasma levels of phenobarbital

Neurology
J BruniH J Villarreal

Abstract

During concurrent administration of phenobarbital and valproic acid, phenobarbital plasma concentrations often increase. This often requires a reduction of phenobarbital dosage. In normal cats and patients with epilepsy, we found no evidence of decreased renal excretion of phenobarbital. Metabolic studies in four patients revealed a decrease in the conversion of phenobarbital to hydroxyphenylphenobarbital and decreased urinary ratios of hydroxyphenylphenobarbital to phenobarbital. These data suggest that phenobarbital metabolism is inhibited by therapeutic plasma levels of valproic acid.

Citations

Jan 1, 1990·Pharmacology & Therapeutics·M Barry, J Feely
Apr 16, 2002·Epilepsia·Philip N PatsalosClementina M van Rijn
Mar 20, 1980·The New England Journal of Medicine·J Koch-Weser, T R Browne
Nov 1, 1994·British Journal of Clinical Pharmacology·I BernusM J Eadie
May 1, 1984·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G R GrannemanJ W Kesterson
Mar 8, 2005·Drug Metabolism Reviews·Shufeng ZhouYu-Zong Chen
Jan 1, 1991·Drug and Chemical Toxicology·R FisherK Brendel
Nov 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J H LewisE Rosenberg
Sep 1, 1988·British Journal of Clinical Pharmacology·P N PatsalosS D Shorvon
Jun 1, 1988·The Japanese Journal of Psychiatry and Neurology·Y WadaN Yamaguchi
Feb 1, 1985·The Journal of Pediatrics·O C Snead, M V Miles
Aug 5, 2016·International Journal of Molecular Sciences·Hueng-Chuen FanChing-Shiang Chi
Sep 1, 1984·Arquivos de neuro-psiquiatria·V J De PaivaM Subirana
Feb 1, 1981·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J Bruni
May 1, 1984·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·P S Albright, J Bruni
Apr 1, 1982·British Journal of Clinical Pharmacology·S Dhillon, A Richens
Sep 1, 1990·The Journal of International Medical Research·L Pérez-GallardoJ F Escanero
Jul 23, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Eyal SobolMeir Bialer
Jan 1, 1990·The Journal of International Medical Research·F PisaniR Di Perri
Aug 1, 1982·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·D L KeeneA Sherwin
May 1, 1985·Pharmacotherapy·E M Rimmer, A Richens

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