PMID: 16645426Apr 29, 2006Paper

Valproic acid and risk of acute pancreatitis: a population-based case-control study

American Journal of Therapeutics
Mette NørgaardHenrik Toft Sørensen

Abstract

To examine whether acute pancreatitis is associated with use of valproic acid. Through the population-based hospital discharge registries we identified all patients with an incident hospitalization of acute pancreatitis in the counties of North Jutland (data 1991 to 2003), Aarhus (data 1996 to 2003), and Viborg (data 1998 to 2003), Denmark. From the Danish Civil Registration System, we selected 10 sex-matched and age-matched population controls per case on the basis of risk set sampling. All prescriptions of valproic acid and other antiepileptic drugs within 90 days (present users) or 91 to 365 days (past users) before hospital admission with acute pancreatitis, or index date among controls, were collected from the prescription databases in the counties. We performed conditional logistic regression to estimate the relative risk of acute pancreatitis after exposure to valproic acid or other antiepileptic drugs, adjusting for gallstone diseases, alcohol-related diseases, hyperlipidemia, and hypercalcemia. We included 3083 cases of acute pancreatitis and 30,830 population controls. The adjusted odds ratio (OR) for acute pancreatitis in present users of valproic acid was 1.9 [95% confidence interval (CI), 1.1-3.3); for past users, ...Continue Reading

References

Dec 1, 1991·Journal of Clinical Gastroenterology·J BinekM Heer
Feb 1, 1991·American Journal of Epidemiology·M A WeinstockF E Speizer
Jan 3, 1981·Lancet·M J MurphyG Mitts
Oct 1, 1984·American Journal of Diseases of Children·E WyllieA D Rothner
Jul 1, 1983·Archives of Disease in Childhood·L H WilliamsJ L Emery
Jan 1, 1980·Annals of Neurology·D L Coulter, R J Allen
Mar 1, 1995·The American Journal of Forensic Medicine and Pathology·R J EvansF J Krolikowski
Jan 1, 1993·Epilepsia·J J AsconapéW Mirza
Jun 1, 1996·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·T Wilmink, T W Frick
Nov 1, 1996·Psychopharmacology·R M PostM A Frye
Oct 3, 1999·Journal of Clinical Psychopharmacology·S E FecikC Lindsey
Dec 15, 2000·Archives of Dermatology·M Szklo
Jan 5, 2002·Pharmacotherapy·S A ChapmanB D Patterson
Nov 9, 2002·Epilepsia·John M PellockKenneth W Sommerville
Apr 18, 2003·Pediatric Neurology·Nancy L Grauso-EbyGary N McAbee

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Citations

Feb 27, 2007·Journal of Gastroenterology·Thorsten GerstnerStephan König
Sep 1, 2007·Current Opinion in Gastroenterology·Matthew J DiMagno, Eugene P DiMagno
Mar 17, 2010·Best Practice & Research. Clinical Gastroenterology·Claudia J NitscheJulia V Mayerle
Jan 31, 2014·Pediatrics International : Official Journal of the Japan Pediatric Society·Akiko TamasakiKousaku Ohno
Oct 19, 2013·The Journal of Surgical Research·John O HwabejireHasan B Alam
Jan 19, 2008·Expert Opinion on Pharmacotherapy·Thorsten GerstnerStephan König
Jul 23, 2009·Arquivos de neuro-psiquiatria·José Guevara-CamposJuan Manuel Rojas
May 16, 2017·Child Neurology Open·Doa Mohamed MahrousAliaa Monir Higazi
Dec 6, 2011·The American Journal of Gastroenterology·James H Grendell
Jan 23, 2008·Proceedings·Tracie Kaurich
May 27, 2014·Journal of Clinical Gastroenterology·Adolfo del Val AntoñanaJuan A Ortuño Cortés

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