Abstract
Valproic acid (VPA) is a commonly used antiepileptic drug (AED). Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis are the rare but fatal cutaneous adverse drug reactions for VPA. We aimed to identify and critically evaluate all the literature of SJS in association with VPA and to describe the clinical features of the condition. A literature search was conducted in MEDLINE/PubMed from inception to December 2017 and updated in July 2018 without any restrictions, and the references of included studies were also searched. The descriptive studies discussing any patients who experienced SJS followed by the use of VPA alone or along with any other AED for its main indication were included. Two authors were independently involved in the study selection and data extraction. Disagreements were resolved by consensus or by the discussion with a third reviewer. A total of 19 studies including 17 case reports and two case series of 98 were included in the review. In all studies, the dose of VPA ranged from 100 mg/day to a maximum dose of 1,000 mg/day and was administered for indications including epilepsy, seizures, schizophrenic affective disorders, and bipolar disorder. The mortality seen with severe cutaneous adverse drug rea...Continue Reading
References
Dec 14, 1995·The New England Journal of Medicine·J C RoujeauF Locati
Oct 28, 1998·Journal of Clinical Psychopharmacology·S J Tsai, Y S Chen
Sep 6, 2000·Clinical and Experimental Dermatology·M BhushanP J August
Feb 13, 2003·International Journal of Immunopathology and Pharmacology·C FelicianiA Tulli
Jul 2, 2003·Journal of the European Academy of Dermatology and Venereology : JEADV·M BabaH R Memişoglu
Mar 26, 2004·Acta Dermato-venereologica·Natasha HashimAndrew Ilchyshyn
Oct 18, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chuan-Chia ChangSan-Yuan Huang
Apr 13, 2007·American Journal of Clinical Dermatology·Sedat KocakEsengul Kaya
Apr 3, 2008·Clinical Neuropharmacology·Sevki SahinSibel Karsidag
Jan 8, 2009·International Journal of Dermatology·Ilgen ErtamIdil Unal
May 25, 2012·International Journal of Critical Illness and Injury Science·Kn NaveenVv Pai
Jun 25, 2013·Clinical Biochemistry·Radu M Nanau, Manuela G Neuman
Oct 2, 2013·Indian Journal of Dermatology·Sukhjot Kaur, Alka Dogra
Jan 15, 2014·Hospital Pharmacy
May 6, 2015·European Journal of Clinical Pharmacology·Elisa Martín-MerinoMiguel Gil
Nov 6, 2015·Journal of Pharmacy & Bioallied Sciences·S KavithaS Kalaivani
Oct 14, 2017·Clinical and Molecular Allergy : CMA·Fabrizio De LucaElide Anna Pastorello
Dec 6, 2017·Epilepsy & Behavior Case Reports·X T WuH Stefan
Citations
Sep 11, 2019·Journal of Basic and Clinical Physiology and Pharmacology·Rajesh VenkataramanShahinur Islam
May 5, 2020·Andrologia·Mehtap SavranDeniz Tastemir Korkmaz
Jan 14, 2020·Seizure : the Journal of the British Epilepsy Association·Muhammed RashidAnanth Kashyap
Mar 17, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Ananth KashyapManik Chhabra
Jun 22, 2021·Cutaneous and Ocular Toxicology·Miloš N MilosavljevićJovana Z Milosavljević
Jun 24, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Manik ChhabraKota Vidyasagar
Jun 24, 2021·BMC Neuroscience·Kyong-Oh ShinPeter M Elias
May 18, 2020·Current Drug Safety·Asha K RajanMuhammed Rashid
Mar 13, 2020·Current Drug Safety·Rajesh VenkataramanHeamant Shrestha
Oct 28, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Mohammed ZuberMuhammed Rashid