Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-κB pathway dependent of HDAC3

Journal of Neuroinflammation
Shoubo ChenShun Li

Abstract

Microglial polarization with M1/M2 phenotype shifts and the subsequent neuroinflammatory responses are vital contributing factors for spinal cord injury (SCI)-induced secondary injury. Nuclear factor-κB (NF-κB) is considered the central transcription factor of inflammatory mediators, which plays a crucial role in microglial activation. Lysine acetylation of STAT1 seems necessary for NF-kB pathway activity, as it is regulated by histone deacetylases (HDACs). There have been no studies that have explained if HDAC inhibition by valproic acid (VPA) affects the NF-κB pathway via acetylation of STAT1 dependent of HDAC activity in the microglia-mediated central inflammation following SCI. We investigated the potential molecular mechanisms that focus on the phenotypic transition of microglia and the STAT1-mediated NF-κB acetylation after a VPA treatment. The Basso-Beattie-Bresnahan locomotion scale, the inclined plane test, the blood-spinal cord barrier, and Nissl staining were employed to determine the neuroprotective effects of VPA treatment after SCI. Assessment of microglia polarization and pro-inflammatory markers, such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and interferon (INF)-γ was used to evaluate the neu...Continue Reading

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Citations

Sep 12, 2018·Journal of Cellular Physiology·Samantha S RomanickBradley S Ferguson
Apr 3, 2019·International Journal of Molecular Sciences·Ping GongYongkui Jing
Jan 29, 2019·Current Topics in Medicinal Chemistry·Yu BaiGuihua Cui
Oct 30, 2019·Current Neuropharmacology·Fan-Cheng KongMing-Kang Zhong
Jun 4, 2020·Experimental Biology and Medicine·Santosh R D'Mello
Jul 30, 2020·Cellular and Molecular Neurobiology·Conghui ZhouXuehong Liu
Nov 28, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Yunpeng ZhangBing Li
Apr 16, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·K P ReisP Pranke
Jul 15, 2020·Journal of Molecular Neuroscience : MN·Sara MirzajaniMohammad Taheri
Nov 1, 2020·Translational Stroke Research·Junxuan LyuJun Chen
Nov 5, 2020·Brain Sciences·Zahara L ChaudhryBushra Y Ahmed
Oct 9, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Marie KühneThorsten Heinzel
Mar 3, 2020·International Immunopharmacology·Bruno Bueno-SilvaMarcia P A Mayer
Jun 24, 2020·Neuropharmacology·Isabel Vieira de Assis LimaAntônio Carlos Pinheiro de Oliveira
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Jun 26, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Lin ChenDaqing Ma
Apr 6, 2021·Aging and Disease·Yimeng XueJizong Zhao
Oct 13, 2021·Clinical Epigenetics·Maria Laura SaizBeatriz Suarez-Alvarez

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Methods Mentioned

BETA
histone acetylation
nuclear translocation
ELISA
ELISAs
electrophoresis
immunoprecipitation
acetylation
co-IP

Software Mentioned

UN
SPSS
It
Image Pro Plus
Scan

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