PMID: 2499082Jan 1, 1989Paper

Valproic acid disposition and protein binding in pregnancy

Therapeutic Drug Monitoring
M KoernerK McCormick

Abstract

Nine epileptic women were followed prospectively through pregnancy on a monthly basis. At each visit, total and free serum valproic acid levels and albumin levels were obtained. Assays were done by gas-liquid chromatography, and free drug was separated by ultrafiltration. Despite an upward dose adjustment in four patients, total valproic acid levels declined as pregnancy proceeded, but free levels did not. Plasma free fractions and clearances increased, but intrinsic clearances, which were adjusted for changes in body weight, remained unchanged.

Citations

Jun 19, 1992·Pharmaceutisch Weekblad. Scientific Edition·S I Johannessen
Jun 1, 1993·Seizure : the Journal of the British Epilepsy Association·P Crawford
Jun 1, 1994·British Journal of Clinical Pharmacology·G D AndersonH R Winn
Nov 9, 2011·Advanced Drug Delivery Reviews·Cecilie Johannessen LandmarkTorbjörn Tomson
Apr 16, 2016·Clinical Pharmacology and Therapeutics·Yasar TasnifMary F Hebert
Jul 22, 2008·Therapeutic Drug Monitoring·Valentina FrancoEmilio Perucca

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