PMID: 15349008Sep 7, 2004Paper

Valproic acid-induced hyperammonemia: a case report

Journal of Clinical Psychopharmacology
Mariposa McCall, James A Bourgeois

Abstract

The authors present a case of a patient treated with valproic acid for seizure disorder who presented with acute mental status changes consistent with encephalopathy. Notably, her serum ammonia level was 3 times the upper limit of normal, despite an only mildly elevated aspartate aminotransferase and normal bilirubin. Her serum valproic acid level was in the therapeutic range. Her symptoms resolved with discontinuation of valproic acid and supportive care. The authors review the possible mechanisms of valproic acid-associated hyperammonemia with encephalopathy and propose clinical practice modifications to minimize the incidence of this adverse reaction to this generally well-tolerated and clinically important psychotropic medication.

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Mar 21, 2007·Journal of General Internal Medicine·Doron RimarHaim Bitterman
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