Valproic Acid Promotes Apoptosis and Cisplatin Sensitivity Through Downregulation of H19 Noncoding RNA in Ovarian A2780 Cells

Applied Biochemistry and Biotechnology
Zahre SajadpoorFarrokh Yadollahi

Abstract

Cisplatin resistance is one of the main limitations in the treatment of ovarian cancer, which is partly mediated by long noncoding RNAs (lncRNAs). H19 is a lncRNA involving in cisplatin resistance in cancers. Valproic acid (VPA) is a commonly used drug for clinical treatment of seizure disorders. In addition, this drug may display its effects through regulation of noncoding RNAs controlling gene expression. The aim of the present study was the investigation of VPA treatment effect on H19 expression in ovarian cancer cells and also the relation of the H19 levels with apoptosis and cisplatin resistance. Briefly, treatment with VPA not only led to significant increase in apoptosis rate, but also increased the cisplatin sensitivity of A2780/CP cells. We found that following VPA treatment, the expression of H19 and EZH2 decreased, but the expression of p21 and PTEN increased significantly. To investigate the involvement of H19 in VPA-induced apoptosis and cisplatin sensitivity, H19 was inhibited by a specific siRNA. Our results demonstrate that H19 knockdown by siRNA induced apoptosis and sensitized the A2780/CP cells to cisplatin-induced cytotoxicity. These data indicated that VPA negatively regulates the expression of H19 in ovari...Continue Reading

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Citations

Apr 26, 2019·Journal of Cellular Biochemistry·Shuran YuHuining Liu
Feb 8, 2020·Journal of Cellular Biochemistry·Caihua DongXia Liu
Oct 30, 2019·Current Neuropharmacology·Fan-Cheng KongMing-Kang Zhong
Jun 26, 2020·Clinical Genetics·He-da ZhangJin-Hai Tang
Jan 24, 2021·Clinical and Experimental Medicine·Samaneh ArabSamira Asgharzade
Jan 17, 2021·Life Sciences·Nastaran InjinariHossein Teimori
Nov 23, 2020·Cancer Letters·Yun Wei Shermane LimBoon-Cher Goh
Sep 6, 2020·European Journal of Pharmacology·Samira AsgharzadeZeinab Amini-Farsani
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Apr 25, 2021·Life Sciences·Somayeh Hashemi SheikhshabaniSamira Asgharzade
Jul 30, 2021·Frontiers in Cell and Developmental Biology·Yu-Jie DongYan Li
Aug 19, 2021·Cancer Cell International·Weiwei XieXipeng Wang

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