PMID: 15235312Jul 6, 2004Paper

Valtrex therapy for Epstein-Barr virus reactivation and upper respiratory symptoms in elite runners

Medicine and Science in Sports and Exercise
Amanda J CoxPeter A Fricker

Abstract

The aim of the study was to examine the effectiveness of prophylactic administration of the antiviral agent Valtrex for control of Epstein-Barr virus (EBV) reactivation and upper respiratory symptoms in elite distance runners. Twenty elite male distance runners were randomized into a 4-month double-blind, placebo-controlled cross-over trial. Saliva samples were collected weekly and mucosal immune status assessed by measurement of secretory IgA (SIgA) using an enzyme-linked immunosorbent assay (ELISA). EBV reactivation was monitored at the same time by detection of EBV in saliva using a quantitative real-time polymerase chain reaction. The initial EBV status of the runners was determined by detecting EBV antibodies in serum using an ELISA. Upper respiratory symptoms were recorded using self-reporting illness logs. There was no evidence of any marked change in maximal oxygen uptake (P = 0.86), training volume (P = 0.30), or mucosal immunity (P = 0.21) over the study period. Valtrex treatment resulted in an 82% reduction in the detectable EBV load in saliva for EBV seropositive runners compared with the placebo treatment (P = 0.04). The incidence of upper respiratory symptoms was not reduced by Valtrex treatment. The prophylactic ...Continue Reading

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Citations

Jul 4, 2009·Oral Microbiology and Immunology·S SahinJ Slots
Nov 8, 2007·Medicine and Science in Sports and Exercise·Amanda Julie CoxMaree Gleeson
Dec 14, 2006·European Journal of Applied Physiology·Paula J Robson-AnsleyMichael Gleeson
Jul 25, 2012·Journal of Medical Virology·Torben PottgiesserGeorg Bauer
Mar 21, 2019·Periodontology 2000·Jørgen Slots, Henrik Slots
Apr 7, 2007·Medicine and Science in Sports and Exercise·Luke SpencePeter A Fricker
Dec 19, 2009·Periodontology 2000·Jørgen Slots
Nov 10, 2009·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Brian CunniffeBruce Davies
Nov 17, 2015·Immunology and Cell Biology·Maree Gleeson, David B Pyne
Oct 9, 2014·Sports Medicine·Veronica VleckFrancisco Bessone Alves
Nov 23, 2021·Research Quarterly for Exercise and Sport·Eleanor Perkins, Glen Davison

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