Valuation of Health and Nonhealth Outcomes from Next-Generation Sequencing: Approaches, Challenges, and Solutions

Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Dean A RegierSarah Wordsworth

Abstract

Next-generation sequencing (NGS) technologies have seen variable adoption in the clinic. This is partly due to a lack of clinical and economic studies, with the latter increasingly challenged to examine patient preferences for health and nonhealth outcomes (e.g., false-positive rate). To conduct a structured review of studies valuing patients' preference-based utility for NGS outcomes, to highlight identified methodological challenges, and to consider how studies addressed identified challenges. We searched MEDLINE (PubMed), Embase (Ovid), and Web of Science for published studies examining outcomes from health care decisions informed by NGS. We focused our search on direct elicitations of preference-based utility. We reviewed included studies and qualitatively grouped and summarized stated challenges and solutions by theme. Eleven studies were included. Most of them (n = 6) used discrete choice experiments to value utility. We categorized challenges into four themes: 1) valuing the full range of NGS outcomes, 2) accounting for accuracy and uncertainty surrounding effectiveness, 3) allowing for simultaneous multiple and cascading risks, and 4) incorporating downstream consequences. Studies found strong evidence of utility for NG...Continue Reading

Citations

May 7, 2020·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Ilias GoranitisTiffany Boughtwood
Jun 27, 2019·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Deborah A MarshallKym M Boycott
Jul 6, 2019·Journal of Community Genetics·Deirdre WeymannDean A Regier
Apr 1, 2020·Journal of Managed Care & Specialty Pharmacy·Devender S DhandaJosh J Carlson
Apr 28, 2020·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Hadley Stevens SmithBrendan H Lee
Aug 26, 2020·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Ilias GoranitisJohn Christodoulou
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Jun 9, 2021·European Journal of Human Genetics : EJHG·You WuIlias Goranitis
Dec 16, 2021·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Robin Z HayeemsM Stephen Meyn

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