Value-based medicine analysis on loop electrosurgical excision procedure and CO2 laser vaporization for the treatment of cervical intraepithelial neoplasia 2

The Journal of Obstetrics and Gynaecology Research
Lu-lu SunKeng Shen

Abstract

The best treatment option for cervical intraepithelial neoplasia 2 (CIN2) is controversial and there is a lack of studies in value-based medicine. This multicenter comparative study was undertaken to evaluate the effectiveness, cost-effectives and quality of life (QOL) of loop electrosurgical excision procedure (LEEP) and CO(2) laser vaporization for the treatment of CIN2. A database of LEEP and laser vaporizations performed at three research centers was created. Patients with colposcopic-histopathologically confirmed CIN2 were randomly submitted to LEEP and laser vaporization. Cytology, human papilloma virus (HPV) DNA test and histology were performed, and a questionnaire on QOL was filled out during follow-up. Effectiveness, cost-effectives and QOL were analyzed. Three hundred and thirty-eight women with CIN2 were included in the study. Frequencies of remission, and persistent and recurrent CIN were 89.2%, 7.2%, and 3.6% for LEEP, and 86.7%, 12.6%, 0.70% for laser, respectively. There was no significant difference in remission and persistence of CIN. There was a significant difference in the number of operations, recovery time and costs. Women treated with two methods showed relatively identical QOL. Both LEEP and CO(2) laser...Continue Reading

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Citations

Jan 25, 2014·Archives of Gynecology and Obstetrics·Bo Sung YoonMi Kyoung Kim
Jun 24, 2015·BJOG : an International Journal of Obstetrics and Gynaecology·M O'ConnorUNKNOWN Irish Cervical Screening Research Consortium (CERVIVA)
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Mar 13, 2018·Journal of Psychosomatic Obstetrics and Gynaecology·Radmila SparićVesna Kesić

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