Value of (18)F-FDG PET/CT in the Detection of Ovarian Malignancy

Nuclear Medicine and Molecular Imaging
Taegyu ParkSungeun Kim

Abstract

Ovarian cancer is a leading cause of gynecologic malignancy. As symptoms of ovarian cancer are nonspecific, only 20 % of ovarian cancers are diagnosed while they are still limited to the ovaries. Thus, early and accurate detection of disease is important for an improved prognosis. For the accurate and effective diagnosis of ovarian malignancy on (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT), we analyzed several parameters, including visual assessment. A total of 51 peritoneal lesions in 19 patients who showed ovarian masses with diffuse peritoneal infiltration were enrolled. Twelve patients were confirmed to have ovarian malignancy and seven patients with benign disease by pathologic examination. All patients were examined by (18)F-FDG PET/CT, and an additional 2-h delayed (18)F-FDG PET/CT was also performed for 15 patients with 42 peritoneal lesions. We measured semiquantitative parameters including maximum and mean standardized uptake values (SUVmax, SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) on a 1-h initial (18)F-FDG PET/CT image (Parameter1) and on a 2-h delayed image (Parameter2). Additionally, retention indices of each parameter were calculat...Continue Reading

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Citations

May 4, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A K L ReynersM Jalving
Mar 13, 2017·Revista española de medicina nuclear e imagen molecular·B González GarcíaÁ M Soriano Castrejón
Sep 20, 2016·Obstetrical & Gynecological Survey·Jorge Daniel Oldan, Parth S Patel
Sep 27, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Amanda J BoyleNeil Vasdev

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