Value of 18F-FET PET in Patients With Suspected Tumefactive Demyelinating Disease-Preliminary Experience From a Retrospective Analysis

Clinical Nuclear Medicine
Massimo BarbagalloMartin W Huellner

Abstract

To investigate the diagnostic value of F-fluoroethyl-L-tyrosine (FET) positron emission tomography (PET) in patients with suspected tumefactive demyelinating disease. We retrospectively examined FET-PET and MR imaging of 21 patients (12 female, 9 male) with known demyelinating disease and newly diagnosed tumefactive lesions. The maximum standardized uptake value (SUVmax), time activity curves (TAC) and lesion-to-background ratio (TBR) of these lesions were calculated. The standard of reference consisted of biopsy and/or follow-up imaging. FET parameters of true neoplastic lesions and tumefactive demyelinating lesions were compared using Mann-Whitney U-test and receiver operating characteristic (ROC) analysis. Nine patients (42.9%) had neoplastic lesions, 12 patients (57.1%) had tumefactive demyelinating lesions. TBRmax, SUVmax and TAC were significantly different between demyelinating lesions and neoplastic lesions: Tumors had a higher TBRmax (3.53 ± 1.09 vs. 1.48 ± 0.31, respectively; P < 0.001) and SUVmax (3.95 ± 1.59 vs. 1.86 ± 0.50, respectively; P < 0.001) than tumefactive demyelinating lesions. The TAC of tumors was significantly higher compared to tumefactive demyelinating lesions at all time points (P < 0.05). ROC analy...Continue Reading

References

Dec 1, 1992·Acta Neurologica Scandinavica·S PoserK Felgenhauer
Sep 1, 1980·Brain : a Journal of Neurology·M AndersonJ A Waterhouse
Jun 1, 1993·The American Journal of Surgical Pathology·D ZagzagG N Budzilovich
Oct 1, 1993·Neurology·K PetersonJ B Posner
Aug 1, 1996·Neuroradiology·A P Dagher, J Smirniotopoulos
Jun 13, 2000·Journal of Neuropathology and Experimental Neurology·D Annesley-WilliamsF M Brett
Sep 11, 2002·Neuroradiology·A Castriota-ScanderbegC Caltagirone
Dec 20, 2003·AJR. American Journal of Roentgenology·Curtis A GivenCharles Lee
Jul 13, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Gabriele PöpperlKlaus Tatsch
Aug 19, 2004·Neuroepidemiology·Marja-Liisa SumelahtiMatti Hakama
Jan 15, 2005·European Journal of Nuclear Medicine and Molecular Imaging·M WeckesserO Schober
Apr 3, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Frank W FloethKarl-Josef Langen
Sep 4, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Gabriele PöpperlKlaus Tatsch
Jan 23, 2008·Multiple Sclerosis : Clinical and Laboratory Research· Chaodong WangYing-Qiong Xiong
Jun 7, 2008·Brain : a Journal of Neurology·C F LucchinettiW Brück
Nov 6, 2009·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Konstantin E BalashovIrwin A Keller
Jun 15, 2011·Expert Review of Clinical Pharmacology·Jörg DietrichSantosh Kesari
Feb 4, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Vincent DunetJohn O Prior
Mar 16, 2012·Multiple Sclerosis : Clinical and Laboratory Research·A AltintasA Siva
Dec 13, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Marion RappKarl-Josef Langen
Mar 1, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Christian P FilssKarl-Josef Langen
Mar 19, 2014·European Journal of Radiology·Jens GemptAnnette Förschler
Mar 20, 2015·Frontiers in Neurology·Domenico PlantoneTatiana Koudriavtseva
Feb 6, 2016·Current Neurology and Neuroscience Reports·Meredith C Frederick, Michelle H Cameron
Nov 12, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Paolo PreziosaMassimo Filippi
Jan 4, 2017·Clinical Nuclear Medicine·Mico Chan, Edward Hsiao
Feb 15, 2017·Clinical Nuclear Medicine·Edit BosnyákCsaba Juhász
Dec 8, 2017·Clinical Nuclear Medicine·Caroline Malo-PionSophie Turpin
Feb 16, 2018·Clinical Imaging·Abdulrahman Abdullah AlbatlyMartin W Huellner

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Citations

Jul 21, 2020·Acta Oncologica·Florian SchneiderMartin W Huellner
Mar 8, 2019·Current Opinion in Neurology·Todd A Hardy
May 20, 2021·AJR. American Journal of Roentgenology·Mariko NakayamaToshio Moritani
Aug 24, 2021·Expert Review of Neurotherapeutics·Pedro SánchezTodd A Hardy
Sep 11, 2021·Clinical Nuclear Medicine·Niklas LohausMartin W Huellner

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