Value of baseline serum thyrotropin as a predictor of hypothyroidism in patients with diabetes mellitus.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Vijay RamasamyO E Okosieme

Abstract

To determine whether serum thyrotropin measurement performed at diagnosis of diabetes mellitus or at initial patient contact predicts subsequent development of hypothyroidism. We retrospectively reviewed the computerized records of patients attending annual visits between January 2008 and December 2008 at a hospital diabetes mellitus clinic. Serum free thyroxine and thyrotropin at current and baseline annual visits were documented. A Cox regression model was used to analyze the relationship between development of thyroid dysfunction and patient characteristics including age, sex, type of diabetes, and baseline serum thyrotropin concentration. Kaplan-Meier survival curves were generated for predictors of hypothyroidism. Clinical records of 1101 patients were reviewed (595 men [54%] and 506 women [46%]). Mean age was 60.0 ± 17 years. Two hundred twenty-three patients (20.3%) had type 1 DM and 878 (79.7%) had type 2 diabetes. Thyroid dysfunction was present in 136 patients (12.4%) at baseline and developed in 71 patients (6.4%) at follow-up (median duration, 37 months). Overt and subclinical hypothyroidism developed in 28 (2.5%) and 38 (3.5%) patients, respectively. Incident hypothyroidism was associated with baseline thyrotropin ...Continue Reading

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Citations

Dec 30, 2011·Medicina clínica·Hector-Eloy Tamez-PérezEnrique Díaz de León-González
Jul 6, 2013·Arquivos brasileiros de endocrinologia e metabologia·Gabriela BrentaUNKNOWN Task Force on Hypothyroidism of the Latin American Thyroid Society (LATS)
Sep 1, 2017·Journal of Endocrinological Investigation·G BellastellaK Esposito

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