Value of bone marrow biopsy in Hodgkin lymphoma patients staged by FDG PET: results from the German Hodgkin Study Group trials HD16, HD17, and HD18

Annals of Oncology : Official Journal of the European Society for Medical Oncology
C-A VoltinC Kobe

Abstract

Bone marrow (BM) involvement defines advanced-stage Hodgkin lymphoma and thus has impact on the assignment to treatment. Our aim was to evaluate whether the established BM biopsy may be omitted in patients if 18F-fluorodeoxyglucose positron emission tomography (PET) scanning is carried out during staging. Our analysis set consisted of 832 Hodgkin lymphoma patients from the German Hodgkin Study Group trials HD16, HD17, and HD18 who underwent both PET scanning and BM biopsy before treatment. All PET studies were centrally reviewed and BM was categorized as showing focal involvement or not. Taking BM biopsy as reference standard, baseline PET showed a negative predictive value of 99.9% [95% confidence interval (CI) 99.2% to 100%] with true-negative results in 702 of 703 cases. The sensitivity of PET for detecting BM involvement was 95.0% (95% CI 75.1% to 99.9%) as it could identify 19 out of 20 patients with positive BM biopsy. Moreover, PET found 110 additional subjects with focal BM lesions who would have been considered negative by biopsy. When compared with BM biopsy, PET was able to detect focal BM lesions in a large number of additional patients. This indicates that conventional BM biopsy may substantially underestimate the ...Continue Reading

Associated Clinical Trials

Aug 13, 2007·Prof. Dr. Andreas Engert
Aug 15, 2008·Prof. Dr. Andreas Engert
May 19, 2011·Prof. Dr. Andreas Engert

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Citations

Jul 28, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A Gallamini
Dec 6, 2019·Asia-Pacific Journal of Clinical Oncology·Shinichi MakitaKensei Tobinai
Mar 11, 2020·Cancers·Conrad-Amadeus VoltinDirk Hellwig
May 16, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Julian M M RogaschCarsten Kobe
Apr 8, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sally F Barrington, Michel Meignan
Jul 3, 2021·Cancers·Katrina M IngleySandra J Strauss
Aug 4, 2021·Case Reports in Hematology·Justin KomisarofMary Anne Morgan
Oct 3, 2021·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lucia BarattoHeike E Daldrup-Link
Dec 29, 2020·The Lancet. Haematology·Judith Trotman, Sally F Barrington
Dec 12, 2021·Scientific Reports·Julie FaudemerCharline Lasnon

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