PMID: 376036Apr 21, 1979Paper

Value of bromocriptine in unexplained primary infertility: a double-blind controlled trial

British Medical Journal
C S WrightH S Jacobs

Abstract

In a double-blind controlled study, 47 women with unexplained primary infertility were allocated at random to treatment with either bromocriptine 2.5 mg twice daily (24 patients) or placebo (23). Both groups showed a fall in serum prolactin concentrations but the reduction was much greater in the bromocriptine-treated group. Neither group showed a change in serum oestrogen or progesterone concentrations. Bromocriptine significantly reduced the duration of the follicular phase of the menstrual cycle but had no effect on the luteal phase. Five women conceived during treatment with placebo and seven during treatment with bromocriptine, but analysis of the cumulative conception rates showed no significant difference between the groups. The women who conceived were significantly younger and had a significantly shorter history of infertility than the women who did not conceive, but subtracting the number of years of infertility from age eliminated this difference. The results show that bromocriptine in the dose and duration of administration used in the trial is of no value in unexplained primary infertility.

References

Oct 1, 1978·Archives of General Psychiatry·N SitaramJ C Gillin
Dec 1, 1978·British Journal of Hospital Medicine·H S Jacobs, C S Wright
Sep 1, 1976·Clinical Endocrinology·H S JacobsJ D Nabarro

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Citations

Feb 1, 1979·Irish Journal of Medical Science·R R O'Moore
Aug 1, 1989·European Journal of Obstetrics, Gynecology, and Reproductive Biology·C A IfflandJ L Beynon
Mar 27, 1980·The New England Journal of Medicine·D G Kissner, J C Jarrett
Oct 1, 1984·European Journal of Obstetrics, Gynecology, and Reproductive Biology·G C Trimbos-KemperE V van Hall
Dec 1, 1989·Baillière's Clinical Obstetrics and Gynaecology·T Friedman
Nov 5, 2011·Chemical Reviews·David R Yarkony
Dec 1, 1992·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J A Collins, P G Crosignani
Jul 20, 2007·The Cochrane Database of Systematic Reviews·E HughesP Vandekerckhove
Nov 1, 1980·Clinical Endocrinology·C GlatthaarC U McRae
Jun 1, 1985·British Journal of Obstetrics and Gynaecology·R J Pepperell, J C McBain
Nov 1, 1993·British Journal of Obstetrics and Gynaecology·P VandekerckhoveT W Harada
Jun 1, 1987·British Journal of Obstetrics and Gynaecology·C M GlazenerM G Hull
Mar 1, 1984·British Journal of Obstetrics and Gynaecology·S K SmithI D Cooke
Feb 9, 1999·Obstetrical & Gynecological Survey·F Zayed, A Abu-Heija
May 1, 1987·Postgraduate Medical Journal·J M Orgogozo, R Spiegel
Jun 1, 1984·Asia-Oceania Journal of Obstetrics and Gynaecology·R J Pepperell
Jun 1, 1990·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·C M GlazenerM G Hull

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