Value of CD123 Immunohistochemistry and Elastic Staining in Differentiating Discoid Lupus Erythematosus from Lichen Planopilaris

International Journal of Trichology
Fatemeh Sari AslaniMojgan Akbarzadeh-Jahromi

Abstract

Differentiating scarring alopecia secondary to lichen planopilaris (LPP) and discoid lupus erythematosus (DLE) has always been a challenge clinically and pathologically. Plasmacytoid dendritic cells (PDCs) have been reported in the cutaneous lupus erythematosus by CD123 immunostaining. This study assesses CD123 marker positivity and patterns of elastic fiber loss in scalp biopsy to differentiate DLE from LLP. Forty-three cases with clinical and pathological diagnosis of LPP and DLE were selected, and CD123 immunohistochemistry staining and elastic staining were performed on them. The presence of CD123-positive cells, clustering and distribution of cells, and patterns of elastic fibers loss in the dermis were evaluated. To analyze the data, the Chi-square test was used; moreover, the sensitivity and specificity of CD123 were calculated based on a diagnostic test for 2-by-2 tables. Infiltration of PDC was seen in 90% of DLE cases. The presence of more than 10% and 20% PDC cells in inflammatory cells had 90% and 85% sensitivity and 34.7% and 91.3% specificity, respectively. PDC clusters more than 20 cells had 100% specificity for DLE. Location and patterns of PDC infiltration were not statistically significant (P = 0.378). The wed...Continue Reading

References

Mar 23, 2000·Journal of Cutaneous Pathology·D M ElstonW F Bergfeld
Jan 11, 2003·Journal of the American Academy of Dermatology·Elise A OlsenUNKNOWN Workshop on Cicatricial Alopecia
Mar 29, 2005·Journal of the American Academy of Dermatology·Paradi MirmiraniVera H Price
Jan 9, 2010·Histopathology·Catherine M Stefanato
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Sep 3, 2013·Archives of Pathology & Laboratory Medicine·David P Arps, Rajiv M Patel
Jun 20, 2015·Dermatology : International Journal for Clinical and Investigative Dermatology·Rima SleimanOssama Abbas
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May 18, 2016·Journal of the American Academy of Dermatology·Athanassios Kolivras, Curtis Thompson
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Jun 21, 2017·The American Journal of Dermatopathology·Dirk M Elston

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