PMID: 8583611Mar 1, 1996Paper

Value of clinical diagnosis in predicting the quality of cryopreserved sperm from cancer patients

The Journal of Urology
Ashok AgarwalA J Thomas

Abstract

Cryopreservation of semen from patients with malignant diseases (primarily testicular cancer, Hodgkin's disease and lymphoma) before specific chemotherapy, radiation or surgical therapy has become a realistic option to preserve fertility. Nevertheless, the post-thaw sperm quality in these patients is poor. Whether the clinical diagnosis of malignancy affects the cryopreservation of human sperm is unknown. Such an association could allow post-thaw sperm quality to be predicted. We compared the effect of cryopreservation on sperm motility, velocity, linearity, amplitude of lateral head movement, motility index and motile sperm count in specimens from 30 normal men, 34 with testicular cancer, 39 with Hodgkin's disease, and 19 with leukemia and lymphoma who were referred for sperm banking during a 5-year period. The pre-freeze and post-thaw motility, motility index and motile sperm count were significantly lower in patients than in normal men (p < 0.01). No significant differences were noted among the patient groups. Similarly, no significant differences were noted after cryopreservation. Our results indicate that the poor pre-freeze sperm quality in some patients with malignancies explains the poor post-thaw results. However, the ...Continue Reading

References

Oct 1, 1990·Current Opinion in Oncology·A M Oza, T A Lister
Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A G KamthanR Stout
Feb 1, 1987·International Journal of Andrology·J G Berthelsen
Jan 1, 1986·Cleveland Clinic Quarterly·S A RothmannA J Thomas
Apr 3, 1981·JAMA : the Journal of the American Medical Association·R M ChapmanJ S Malpas
Jun 1, 1980·Urology·R B Bracken, K D Smith

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Citations

Jul 1, 1997·Journal of Assisted Reproduction and Genetics·R S SidhuA Agarwal
Jun 23, 2005·Der Urologe. Ausg. A·M BoltenR Kaden
Feb 1, 1997·Fertility and Sterility·O F PadronA Agarwal
Mar 26, 2003·Mutation Research·Silvina M RichardNéstor O Bianchi
Nov 6, 2004·Journal of Assisted Reproduction and Genetics·J M MorrellP V Holmes
Jun 13, 2000·International Journal of Andrology·A Agarwal
Oct 27, 1998·Journal of Pediatric Hematology/oncology·L R SchoverA J Thomas
Oct 4, 2005·British Journal of Haematology·Mark F H Brougham, W H B Wallace
Jun 23, 2009·International Journal of Andrology·Niels J van CasterenGert R Dohle
Mar 29, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leslie R SchoverSima Jeha
Dec 1, 2001·Human Reproduction·S KelleherD J Handelsman

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