Value of colonoscopy for prediction of prognosis in patients with ulcerative colitis.

World Journal of Gastroenterology : WJG
Takafumi AndoHidemi Goto

Abstract

Ulcerative colitis (UC) is a chronic inflammatory bowel disorder characterized by exacerbations and remissions. Some UC patients remain refractory to conventional medical treatment while, in others, the effectiveness of drugs is limited by side-effects. Recently, cyclosporine and leukocyte removal therapy have been used for refractory UC patients. To predict the efficacy of these therapies is important for appropriate selection of treatment options and for preparation for colectomy. Endoscopy is the cornerstone for diagnosis and evaluation of UC. Endoscopic parameters in patients with severe or refractory UC may predict a clinical response to therapies, such as cyclosporine or leukocyte removal therapy. As for the patients with quiescent UC, relapse of UC is difficult to predict by routine colonoscopy. Even when routine colonoscopy suggests remission and a normal mucosal appearance, microscopic abnormalities may persist and relapse may occur later. To more accurately identify disease activity and to predict exacerbations in UC patients with clinically inactive disease is important for deciding whether medical treatment should be maintained. Magnifying colonoscopy is useful for the evaluation of disease activity and for predicti...Continue Reading

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Citations

Jun 3, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Walter ReinischPeter D R Higgins
Dec 22, 2010·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·You Suk OhGyu Yong Choi
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Jenna MorganSarah Braungart
Aug 24, 2018·International Journal of Molecular Sciences·Nicole DmochowskaPatrick A Hughes
Jan 27, 2016·World Journal of Gastroenterology : WJG·Elisa LiveraniAndrea Belluzzi

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