Value of combined detection of serum carcino-embryonic antigen, carbohydrate antigen 19-9 and cyclooxygenase-2 in the diagnosis of colorectal cancer

Oncology Letters
Weili YangQing Liu

Abstract

The aim of the present study was to investigate the value of combined detection of serum carcino-embryonic antigen (CEA), carbohydrate antigen (CA) 19-9 and cyclooxygenase-2 (COX-2) in the diagnosis of colorectal cancer. A total of 50 patients with colorectal cancer were selected as Group A and 50 healthy subjects as the control group. A sample of 2 ml fasting venous blood was drawn from patients in each group, and serum CEA, CA19-9 and COX-2 were detected using electrochemiluminescence analyzer and ELISA. Receiver operating characteristic curve analysis was performed on analyze the sensitivity and specificity of diagnostic methods for colorectal cancer patients at different stages. The expression levels of CEA, CA199 and COX-2 in the cancer patients group were significantly higher than those in the healthy group (P<0.05). The coincidence rates of CEA, CA199, COX-2 and combined detection were 56.0, 64.0, 62.0 and 88.0%, respectively. The coincidence rate of combined detection was significantly higher than that of diagnosis using a single factor (P<0.05). Sensitivity of combined detection of colorectal cancer patients with stage I, II, III and IV were 82.9, 85.3, 86.4 and 88.7%, respectively. The specificities were 65.3, 68.7, 5...Continue Reading

References

Mar 5, 2013·International Journal of Cancer. Journal International Du Cancer·Shuyang WangHongguang Zhu
Apr 30, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Xue-Yan Wu, Xin-En Huang
May 20, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Jin Liu, Xin-En Huang
Jun 5, 2015·Gut·Eline H SchreudersErnst J Kuipers
Jul 8, 2015·Oncology Reports·Marina De RosaPaolo Delrio
Jul 15, 2015·Clinical Proteomics·Chuncui HuangYan Li
Nov 2, 2015·Gastroenterología y hepatología·Antoni Castells
Nov 10, 2015·Cancer Cell International·Bing LiuShigui Yan
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 28, 2016·JAMA : the Journal of the American Medical Association·Albert L SiuMichael P Pignone
Feb 11, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marina BacacPablo Umana
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

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BETA
enzyme-linked immunosorbent assay
imaging techniques

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SPSS

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