Value of computer-assisted quantitative nuclear morphometry for differentiation of reactive renal tubular cells from low-grade urothelial carcinoma

Cytopathology : Official Journal of the British Society for Clinical Cytology
H OhsakiR Haba

Abstract

To assess whether computer-assisted quantitative morphological parameters can be an effective tool for objectively distinguishing reactive renal tubular cells from low-grade urothelial carcinoma cells (LG-UCs) in voided urine. Nuclear morphometry was performed by a computer-assisted image analyser system on Papanicolaou-stained cytological specimens. The circumference of reactive renal tubular cells (n = 40) or LG-UC (n = 20) nuclei were manually traced, and the following nuclear morphometric parameters were analysed: (i) area, (ii) perimeter, (iii) roundness factor, (iv) maximum length, and (v) linear factor. For each nuclear measurement, we calculated the maximum, minimum, mean and standard deviation. The mean nuclear area and nuclear perimeter were higher in reactive renal tubular cells compared to the LG-UCs. The mean of roundness and linear factors (reflecting a tendency for the nuclear outline to be regular and oval, respectively) were higher in LG-UCs compared with reactive renal tubular cells. Among nuclear areas, the nuclear perimeter, roundness factors and maximum length did not show any significant differences between reactive renal tubular cells and LG-UCs. On the other hand, the linear factor showed a mean higher v...Continue Reading

References

Oct 6, 2000·Urology·H G van der PoelJ A Schalken
Aug 7, 2004·Acta Cytologica·Shin-ichi MurataRyohei Katoh
Oct 7, 2004·Diagnostic Cytopathology·Gia-Khanh Nguyen, Roxanne Smith
Mar 11, 2006·European Urology·Paula M J MoonenJ Alfred Witjes
Jan 29, 2010·Cytopathology : Official Journal of the British Society for Clinical Cytology·H OhsakiR Haba

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Citations

Jun 2, 2012·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Hye-Yon ChoKidong Kim
Sep 13, 2013·Der Urologe. Ausg. A·M BöhmUNKNOWN Arbeitskreis Urinzytologie der DGU (Deutsche Gesellschaft für Urologie)
Dec 7, 2011·Cytopathology : Official Journal of the British Society for Clinical Cytology·L PantanowitzW E Khalbuss
Jun 29, 2011·Diagnostic Cytopathology·S A Thiryayi, D N Rana
May 2, 2015·Histochemistry and Cell Biology·Franziska ErlmeierGregor Weirich
Dec 7, 2018·Cytopathology : Official Journal of the British Society for Clinical Cytology·Ryuko TsukamotoChiho Ohbayashi

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