Value of diffusion-weighted MRI in diagnosis of uterine cervical cancer: a prospective study evaluating the benefits of DWI compared to conventional MR sequences in a 3T environment

Acta Radiologica
Marc ExnerPhilipp Brandmaier

Abstract

Imaging of cervical carcinoma remains challenging as local infiltration of surrounding tissues cannot always be discriminated safely. New imaging techniques, like diffusion-weighted imaging (DWI) have emerged, which could lead to a more sensitive tumor detection. To evaluate the benefits of DWI for determination of size, local infiltration, and tumor grading, in patients with primary and recurrent cervical cancer. In this prospective, study we enrolled 50 patients with primary (n = 35) and recurrent (n = 15) tumors. All patients underwent 3T magnetic resonance imaging (MRI) including conventional (e.g. T1/T2 ± fs ± contrast) sequences and DWI (b-values of 0, 50, 400, 800 s/mm(2)). All images were analyzed by three readers with different experience levels (1, 3, 6 years), who compared image quality, tumor delineation, dimensions, local infiltration, lymph node involvement, and quantified ADC values compared to the histopathological grading. Additional use of DWI resulted in significantly better (P < 0.001) tumor delineation for the least experienced reader, but not for experienced readers. Tumor dimensions were assessed almost equally (P > 0.05) in conventional sequences and DWI. Use of DWI led to an increase in sensitivity of i...Continue Reading

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Citations

Apr 10, 2018·The British Journal of Radiology·Jiyoung HwangHwajin Cha
Jun 9, 2017·Current Opinion in Oncology·Vincent VandecaveyeFrederik De Keyzer
Jul 31, 2019·Current Oncology Reports·Ingfrid S HaldorsenHenrica M J Werner
Aug 23, 2017·Insights Into Imaging·Evelyn DappaAndreas M Hötker
Dec 11, 2020·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Rishabh KumarSanjeet Mandal
Mar 3, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Vincent VandecaveyeRaphaëla Carmen Dresen
May 15, 2021·The British Journal of Radiology·Aki Kido, Yuji Nakamoto
Apr 30, 2021·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K PálsdóttirE Epstein
Nov 4, 2021·Future Oncology·Emmanuel Kwateng DrokowKai Sun

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Methods Mentioned

BETA
hysterectomy
imaging techniques

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via
SPSS®

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