Value of exercise echocardiography for predicting mortality in elderly patients

European Journal of Clinical Investigation
Alberto Bouzas-MosqueraAlfonso Castro-Beiras

Abstract

Elderly patients with suspected or known coronary artery disease are often referred for pharmacological stress testing. Data on the value of exercise echocardiography (ExEcho) for predicting outcome (particularly all-cause mortality) in these patients are scarce. Peak treadmill ExEcho was performed in 2159 patients ≥ 70 years of age with known or suspected coronary artery disease. Left ventricular wall motion was evaluated at baseline and with exercise, and the increase in wall motion score index from rest to peak exercise (ΔWMSI) was calculated. Ischaemia was diagnosed when new or worsening wall motion abnormalities developed with exercise. The end points were all-cause mortality and major cardiac events (cardiac death or myocardial infarction). Ischaemia developed in 844 patients (38·6%) during exercise. Over a mean follow-up of 3·5 ± 3·1 years, 439 deaths occurred. The cumulative 5-year mortality rate was 29·3% in patients with ischaemia versus 16·8% in those without ischaemia (P < 0·001). After covariate adjustment, ΔWMSI remained an independent predictor of mortality [hazard ratio (HR) 2·37, 95% confidence interval (CI) 1·66-3·39, P < 0·001] and major cardiac events (HR 3·48, 95% CI 2·11-5·74, P < 0·001). These results rem...Continue Reading

References

Jun 1, 1992·Journal of the American College of Cardiology·L ShawD D Miller
Sep 1, 1989·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·N B SchillerI Schnittger
Feb 1, 1983·Journal of the American College of Cardiology·G A Diamond
Sep 14, 1999·Journal of the American College of Cardiology·M S LauerE J Topol
Dec 10, 1999·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·J PeteiroA Castro-Beiras
Mar 27, 2001·Journal of the American College of Cardiology·A M ArrudaP A Pellikka
May 12, 2001·The American Journal of Cardiology·A M ArrudaP A Pellikka
Feb 19, 2002·Journal of the American College of Cardiology·Adelaide M Arruda-OlsonPatricia A Pellikka
Apr 17, 2002·Journal of the American College of Cardiology·Michael S LauerUNKNOWN American Heart Association
Dec 6, 2002·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Richard M SteingartMartin Feuerman
Aug 21, 2003·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·J PeteiroA Castro-Beiras
Jul 28, 2004·The American Journal of Cardiology·Jesus PeteiroAlfonso Castro-Beiras
Sep 29, 2004·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Jesús PeteiroAlfonso Castro-Beiras
Nov 12, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Elena BiaginiDon Poldermans
Sep 4, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Patricia A PellikkaUNKNOWN American Society of Echocardiography
Jun 27, 2008·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Rosa SicariUNKNOWN European Association of Echocardiography
Jan 27, 2009·European Heart Journal·Jesús Peteiro, Alberto Bouzas-Mosquera
Apr 10, 2009·JACC. Cardiovascular Imaging·Alberto Bouzas-MosqueraAlfonso Castro-Beiras
May 23, 2009·Journal of the American College of Cardiology·Alberto Bouzas-MosqueraAlfonso Castro-Beiras
Mar 6, 2010·Reviews on Recent Clinical Trials·Jesus Peteiro, Alberto Bouzas-Mosquera

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Citations

Jul 17, 2012·The American Journal of Cardiology·Mridula RaiGary Vashon Heller
Sep 22, 2015·European Journal of Internal Medicine·Alberto Bouzas-MosqueraJosé Manuel Vázquez-Rodríguez
Jul 24, 2013·Circulation·Gerald F FletcherUNKNOWN American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee of the Council on Clinical Cardiology,
Dec 17, 2010·World Journal of Cardiology·Jesus Peteiro, Alberto Bouzas-Mosquera

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