PMID: 11900953Mar 20, 2002Paper

Value of existing serological tests for identifying badgers that shed Mycobacterium bovis

Veterinary Microbiology
M A ChambersR G Hewinson

Abstract

In the UK there has been a sharp rise in the incidence of bovine tuberculosis since the early 1990s and the badger has been identified as an important wildlife reservoir for this infection. Infected badgers can excrete Mycobacterium bovis, putting other badgers and cattle at risk of becoming infected. Vaccination has been proposed as an approach to reducing the excretion of M. bovis by tuberculous badgers. In order to evaluate the efficacy of a badger vaccine it will be necessary to accurately determine the number of badgers excreting M. bovis without removing them for post-mortem evaluation. The existing live tests for tuberculosis in the badger (culture, indirect ELISA, Western blot) have not been assessed for their ability to detect badgers excreting M. bovis. Over the past 18 years, badgers from 31 social groups have been trapped and sampled in a study area of the Cotswold escarpment. We have examined the serological responses of 128 badgers trapped between 1985 and 1998 from social groups where M. bovis infection was endemic. These responses were compared with culture from faeces, urine, tracheal aspirates and bite wound swabs taken from these animals while alive. ELISA was found to be more sensitive than Western blot in d...Continue Reading

References

Nov 25, 1995·The Veterinary Record·R S Clifton-HadleyM P Stock
Dec 22, 2000·Research in Veterinary Science·J Gallagher, R S Clifton-Hadley

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Citations

Oct 8, 2013·The Veterinary Journal·Suzanne S BaileyChristopher J Palgrave
Jul 18, 2003·Diagnostic Microbiology and Infectious Disease·Rena GreenwaldKonstantin Lyashchenko
Mar 26, 2013·Epidemiology and Infection·A J TomlinsonR J Delahay
Nov 6, 2009·Proceedings. Biological Sciences·Julian A Drewe
Dec 3, 2010·Proceedings. Biological Sciences·Mark A ChambersR Glyn Hewinson
Mar 29, 2011·Veterinary Microbiology·Elizabeth Mullineaux, Pauline Kidner
Dec 12, 2012·Comparative Immunology, Microbiology and Infectious Diseases·M MaasV P M G Rutten
Nov 22, 2018·Frontiers in Veterinary Science·Graham C Smith, Richard J Delahay
Feb 9, 2017·Frontiers in Cellular and Infection Microbiology·Mark A ChambersSandrine Lesellier
Nov 14, 2019·Comparative Immunology, Microbiology and Infectious Diseases·Elisabeth M D L van der HeijdenAnita L Michel
Oct 22, 2003·The Veterinary Record·S KämpferM Singh

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