Value of extranodal extension detected by computed tomography for predicting clinical response after chemoradiotherapy in head and neck squamous cell cancer

Acta Oto-laryngologica
Hyun MoonSang Yoon Kim

Abstract

Radiological extranodal extension (rENE) upon CT is obtained before concurrent chemoradiation therapy (CCRT) for head and neck squamous cell carcinoma (HNSCC). We evaluated the prognostic value of rENE, rather than pathologically proven ENE, in patients who received CCRT for HNSCC. We reviewed 117 patients. We divided the patients into rENE(+) and rENE(-) groups and evaluated overall survival (OS) and disease-specific survival (DSS), and factors affecting these outcomes. Median follow-up was 37.4 months; 31 patients (26.2%) died and 26 (22.2%) had recurrence. Thirty patients were rENE(+) and these had worse 5-year OS (74% vs. 94%, p < .01) and DSS (42% vs. 84%, p < .01) rates compared with the rENE(-) group (n = 87). rENE (hazard ratio [HR] 3.57, p < .05) and complete response (HR 3.55, p < .05) affected OS. Clinical T stage (HR 2.86, p < .05), rENE (HR 2.88, p < .05), and complete response (HR 7.03, p < .01) affected DSS. rENE(+) increased risk of incomplete response (IR) compared with the rENE(-) group (p < .05). CT findings suggesting ENE predicts treatment response to CCRT and prognosis, and could be used to determine the treatment modality for HNSCC.

References

Mar 11, 2003·Cancer·Jayson S GreenbergJeffrey N Myers
May 7, 2004·The New England Journal of Medicine·Jacques BernierUNKNOWN European Organization for Research and Treatment of Cancer Trial 22931
Sep 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anthony J CmelakArlene A Forastiere
Jun 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mitchell MachtayK Kian Ang
Nov 28, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arlene A ForastiereJay S Cooper
Jul 10, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pierre BlanchardUNKNOWN Meta-Analysis of Chemotherapy in Head and Neck Cancer, Induction Project, Collaborative Group
Dec 18, 2013·International Journal of Radiation Oncology, Biology, Physics·Roshan S PrabhuJonathan J Beitler
Apr 23, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Kyoungjune PakDong Soo Lee

❮ Previous
Next ❯

Citations

May 20, 2021·American Society of Clinical Oncology Educational Book·Shao Hui HuangCarole Fakhry

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.