PMID: 12523164Jan 14, 2003Paper

Value of free testosterone and estrogen-progesterone receptor concentration in juvenile patients with angiofibroma

Otolaryngologia polska. The Polish otolaryngology
A Kruk-ZagajewskaAnna Thielemann


The same localisation, age and sex patients at juvenile nasopharyngeal angiofibroma may suggest relation its pathogenesis to hormonal changes of pubertal period. The examined group comprised 3 juvenile nasopharyngeal angiofibroma patients treated in ENT Clinic of K. Marcinkowski University of Medical Sciences in Poznań. There was estimated free testosterone (fT) level in blood serum. It was used radioimmunological assay Spectria by Orion Diagnostica. The concentration of estrogen and progesterone receptors was estimated by immunoenzymatic assay ER-EIA and PgR-EIA by Abbott. The quality assessment was done both in cytoplasmatic and nuclear receptors. There were normal value of free testosterone in blood serum at all patients. Samples of juvenile nasopharyngeal angiofibroma contain estrogen and progesterone receptors. We found much higher concentration of nuclear receptors comparing to cytoplasmatic ones.

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