Value of hepatocellular phase imaging after intravenous gadoxetate disodium for assessing hepatic metastases from gastroenteropancreatic neuroendocrine tumors: comparison with other MRI pulse sequences and with extracellular agent

Abdominal Radiology
Sree Harsha TirumaniAtul B Shinagare

Abstract

To compare hepatocellular phase imaging after intravenous gadoxetate disodium with other MRI pulse sequences and with extracellular agent for assessing hepatic metastases from gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN). In this IRB-approved, HIPAA-compliant retrospective study, we included 30 patients (15 women, mean age: 58 years, range 44-77 years) with GEP-NEN metastatic to the liver, who underwent MRI with gadoxetate disodium. Six MRI sequences were reviewed by two radiologists to score tumor-liver interface (TLI) on a 5-point scale, to assess lesion detectability in different liver segments (divided into 3 zones/patient), and to measure lesion size. Contrast-to-noise ratio (CNR) was calculated on each sequence. In 19 patients, lesion size and CNR on dynamic imaging with gadopentetate dimeglumine was compared with hepatocellular phase. Wilcoxon signed-rank test was used to compare TLI scores, lesion size, and median CNR, using Bonferroni correction for multiple testing. Interobserver agreement for TLI was analyzed using Krippendorff's alpha, and for lesion size using concordance correlation coefficient (CCC) and mean relative difference. Hepatocellular phase had the best TLI (mean TLI for reader 1 = 1.2, read...Continue Reading

References

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Dec 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Clarisse DromainEric Baudin
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Citations

Apr 12, 2019·AJR. American Journal of Roentgenology·Akshya GuptaPerry J Pickhardt
Jun 11, 2020·Clinical Nuclear Medicine·Nghi C NguyenAlessandro Furlan
Jul 31, 2020·Current Treatment Options in Oncology·Brian MorseJaime Montilla-Soler
Mar 11, 2020·Surgical Oncology Clinics of North America·Aaron T Scott, James R Howe
Jul 3, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Thomas A HopeJonathan R Strosberg
Jun 3, 2021·Abdominal Radiology·Christopher L WelleJeff L Fidler
Nov 12, 2020·Academic Radiology·Mehmet Ali GultekinAlpay Alkan

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