Value of inhibin in the identification of granulosa cell tumors of the ovary

Human Pathology
R H HildebrandtTeri A Longacre

Abstract

Inhibins are peptide hormones that participate in the regulation of the pituitary-gonadal feedback system and are selectively expressed by cells of sex cord-stromal derivation. To determine the efficacy of this marker for distinguishing granulosa cell tumors, 134 primary and metastatic lesions of the ovary were evaluated for expression of the alpha-subunit of inhibin in routinely processed formalin-fixed, paraffin-embedded tissue. A variety of sex cord-stromal tumors (SCST), including 35 adult and juvenile granulosa cell tumors, 14 fibroma-thecomas, and 18 other sex cord-stromal proliferations, were studied. In addition, 33 surface epithelial neoplasms, 12 germ cell tumors, 11 metastases, and 11 miscellaneous ovarian neoplastic proliferations were evaluated. Among the non-granulosa cell neoplasms, special emphasis was placed on primary neoplasms and metastases that histologically simulated granulosa cell tumors. Thirty-three of 35 (94%) granulosa cell tumors were immunoreactive compared with 2 of 12 (17%) primary ovarian endometrioid tumors, one of nine (11%) primary ovarian transitional cell (Brenner) proliferations, and 3 of 17 (18%) other primary and metastatic poorly differentiated (undifferentiated) carcinomas. In 31 of th...Continue Reading

References

Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·S Chadha, T H van der Kwast
Jan 1, 1989·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·M R WickR E Fechner
Jan 1, 1989·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·P AguirreR E Scully
Jan 1, 1989·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·B CzernobilskyG Gabbiani
Sep 21, 1989·The New England Journal of Medicine·R E LappöhnH W de Bruijn
Nov 1, 1987·The Journal of Clinical Endocrinology and Metabolism·R I McLachlanD M de Kretser
Jan 1, 1983·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·M MiettinenI Virtanen
Apr 1, 1995·Gynecologic Oncology·C J GurusingheH G Burger
Aug 1, 1993·Cell and Tissue Research·M K VliegenE Nieschlag
Nov 18, 1993·The New England Journal of Medicine·D L HealyJ J Campbell
Jun 1, 1996·The American Journal of Surgical Pathology·J D Seidman
May 1, 1997·The American Journal of Surgical Pathology·M RishiF A Tavassoli

❮ Previous
Next ❯

Citations

Jul 10, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N ColomboUNKNOWN ESMO Guidelines Working Group
Nov 20, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N ColomboUNKNOWN ESMO Guidelines Working Group
Jul 13, 2000·Journal of Clinical Pathology·W G McCluggage
Aug 16, 2011·The American Journal of the Medical Sciences·Hongmei XuJin He
Mar 12, 2013·Annales de pathologie·Caroline CapuaniMarie-Bernadette Delisle
Jan 3, 2009·Gynécologie, obstétrique & fertilité·N KalfaC Sultan
Mar 4, 2006·Seminars in Diagnostic Pathology·Robert E Emerson, Thomas M Ulbright
Apr 16, 2016·Gynecologic Oncology·William D FoulkesW Glenn McCluggage
Jul 28, 2011·Taiwanese Journal of Obstetrics & Gynecology·Dah-Ching Ding, Tang-Yuan Chu
Oct 1, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Justine Hugon-RodinNajiba Lahlou
Jul 5, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Elena RiccardiMario Finazzi
Mar 22, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Michael T DeaversElvio G Silva
Feb 24, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W G McCluggage
Aug 13, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S KusamuraL A L A Andrade
Aug 25, 2007·Advances in Anatomic Pathology·Julie A Irving, W Glenn McCluggage
Aug 28, 2007·The American Journal of Surgical Pathology·Chengquan ZhaoRussell Vang
Aug 30, 2008·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Chengquan ZhaoRussell Vang
Feb 15, 2019·The Journal of Obstetrics and Gynaecology Research·Selçuk ErkılınçMuzaffer Sancı
Jun 16, 1999·Current Opinion in Obstetrics & Gynecology·F PetragliaF M Reis
Feb 8, 2007·The American Journal of Dermatopathology·Briana C Gleason, Alessandra F Nascimento
Feb 2, 2013·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Longwen Chen, Bin Yang
Sep 16, 1998·The American Journal of Surgical Pathology·S KrishnamurthyJ Rosai
Dec 12, 2001·Endocrine Reviews·G P RisbridgerD M Robertson
Oct 16, 2015·Applied Immunohistochemistry & Molecular Morphology : AIMM·Geralyn Lambert-MesserlianRichard Moore
Feb 8, 2020·Indian Journal of Pathology & Microbiology·Prerna GuleriaSandeep R Mathur
Apr 16, 2019·The American Journal of Surgical Pathology·Anthony N KarnezisFriedrich Kommoss
Mar 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan Tinsley Schumer, Stephen A Cannistra
Nov 19, 2020·Gynecologic Oncology Reports·Erica V CarballoDavid M Kushner

❮ Previous
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