Value of intravoxel incoherent motion in detecting and staging liver fibrosis: A meta-analysis

World Journal of Gastroenterology : WJG
Zheng YeBin Song

Abstract

Liver fibrosis (LF) is a common pathological feature of all chronic liver diseases. With the accumulation of extracellular matrix in the fibrotic liver, true molecular water diffusion and perfusion-related diffusion are restricted. Intravoxel incoherent motion (IVIM) can capture the information on tissue diffusivity and microcapillary perfusion separately and reflect the fibrotic severity with diffusion coefficients. To investigate the diagnostic performance of IVIM in detecting and staging LF with histology as a reference standard. A comprehensive literature search was conducted to identify studies on the diagnostic accuracy of IVIM for assessment of histologically proven LF. The stages of LF were classified as F0 (no fibrosis), F1 (portal fibrosis without septa), F2 (periportal fibrosis with few septa), F3 (septal fibrosis), and F4 (cirrhosis) according to histopathological findings. Data were extracted to calculate the pooled sensitivity, specificity, positive and negative likelihood ratios, and diagnostic odds ratio, as well as the area under the summary receiver operating characteristic curve (AUC) in each group. A total of 12 studies with 923 subjects were included in this meta-analysis with 5 studies (n = 465) for LF ≥ F...Continue Reading

References

Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Feb 20, 2003·Journal of Hepatology·Scott L Friedman
Oct 3, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kevin M BennettJames S Hyde
Dec 4, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pierre BedossaValerie Paradis
Jul 14, 2006·BMC Medical Research Methodology·Javier ZamoraArri Coomarasamy
Nov 18, 2008·Radiology·Alain LucianiAlain Rahmouni
Jan 22, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stella M MartínezXavier Forns
Oct 19, 2011·Annals of Internal Medicine·Penny F WhitingUNKNOWN QUADAS-2 Group
Jan 27, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Qing-Bing WangBei Zhang
Nov 22, 2013·Journal of Magnetic Resonance Imaging : JMRI·Stephan W AndersonHernan Jara
Jan 1, 2014·Journal of Computer Assisted Tomography·Jeong Hee YoonByung-Ihn Choi
Jan 31, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alexander D CohenKathleen M Schmainda
Jul 22, 2014·Journal of Magnetic Resonance Imaging : JMRI·Benjamin LeporqOlivier Beuf
Nov 22, 2014·Acta Radiologica·Sae Rom ChungIn Seong Kim
Apr 29, 2015·Journal of Hepatology·Christian TrautweinMassimo Pinzani
Sep 24, 2015·European Journal of Radiology Open·Yong CuiBachir Taouli
Aug 23, 2017·Abdominal Radiology·Kumaresan SandrasegaranChen Lin
Dec 27, 2017·NeuroImage·Denis Le Bihan
Sep 15, 2018·Molecular Aspects of Medicine·Maurizio Parola, Massimo Pinzani
Mar 29, 2019·World Journal of Gastroenterology : WJG·Tarek BesheerMahmoud El-Bendary
Apr 4, 2019·Journal of Magnetic Resonance Imaging : JMRI·Andreas Julian RiexingerFrederik Bernd Laun

❮ Previous
Next ❯

Citations

Jun 18, 2021·Advanced Drug Delivery Reviews·Alexandros Marios SofiasTwan Lammers

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
imaging

Software Mentioned

Disc
IVIM
Meta
Ovid MEDLINE
Google Scholar
Reviewer Manager
Stata
METAVIR

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.