Value of labial salivary gland histopathology for diagnosis of Sjögren's syndrome in patients with anti-centromere antibody positivity.

International Journal of Rheumatic Diseases
Masako TsukamotoTsutomu Takeuchi

Abstract

Although anti-centromere antibody (ACA)+ Sjögren's syndrome (SS) is considered a subtype of SS, it was not included in the recent American College of Rheumatology/ European League Against Rheumatism (ACR/EULAR) SS classification criteria. ACA+ patients without anti-SS-A/Ro antibodies require salivary gland histopathology to fulfill the ACR/EULAR criteria for diagnosis of SS. We reviewed salivary gland histology among ACA+ patients referred for the diagnosis of SS using the ACR/EULAR and Japanese criteria which does not require biopsy. Data from 147 ACA+ patients with dry eyes and/or mouth who visited our department were retrospectively analyzed. Clinical, immunological, and histological data were collected and statistically analyzed. Sixty-five patients (44%) had undergone labial salivary gland biopsy. The frequency of dry mouth was higher in ACA+ patients who had undergone labial salivary gland biopsy than in those who had not (P = .046), while there were no differences in biopsy rates between patients with and without sclerodactyly (P = .51). According to the current ACR/EULAR classification criteria, Greenspan grade of 3 or 4 for labial salivary gland histopathology is required in patients without anti-SS-A/Ro antibody for t...Continue Reading

References

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Apr 12, 2011·Arthritis and Rheumatism·Troy E DanielsUNKNOWN Sjögren's International Collaborative Clinical Alliance Research Groups
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Jun 16, 2012·BMJ : British Medical Journal·Manuel Ramos-CasalsXavier Bosch
Jul 4, 2012·Journal of Autoimmunity·Divi CornecAlain Saraux
Sep 21, 2013·Annual Review of Pathology·Clio P Mavragani, Haralampos M Moutsopoulos
Dec 1, 2004·Modern Rheumatology·Takashi FujibayashiKazuo Tsubota
Sep 27, 2018·Rheumatology and Therapy·Masako TsukamotoTsutomu Takeuchi
Nov 15, 2018·International Journal of Rheumatic Diseases·Masako TsukamotoTsutomu Takeuchi

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