Value of Memorial Sloan-Kettering Cancer Center nomogram in clinical decision making for sentinel lymph node-positive breast cancer

The British Journal of Surgery
I van den HovenR M H Roumen

Abstract

The aim of this study was to determine the value of the Memorial Sloan-Kettering Cancer Center (MSKCC) nomogram for individual decision making in a Dutch cohort of women with breast cancer with a positive sentinel lymph node (SLN) but at low risk of additional nodal metastases. Data were collected on 168 patients with a positive SLN who underwent completion axillary lymph node dissection. The predicted probability of non-SLN metastases was calculated for each patient, using the MSKCC nomogram. Specificity and false-negative rates were calculated for subgroups with a predicted risk of no more than 5, 10 or 15 per cent. A receiver operating characteristic (ROC) curve was constructed and the area under the curve (AUC) calculated. The discrimination of the MSKCC nomogram, measured by the AUC, was 0.68. For low predicted probability cut-off values of no more than 5, 10 and 15 per cent, the false-negative rates were 20, 14 and 19 per cent, and the specificities were 4, 27 and 32 per cent, respectively. The low-risk category (5 per cent or less) consisted of only 3.0 per cent of the study population. The performance of the MSKCC nomogram was insufficient to make it a useful tool for individual decision making in this cohort of women w...Continue Reading

References

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Citations

Aug 3, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Antonio PiñeroUNKNOWN Members of the Group for Senologic Studies of the Spanish Society of Senology
Dec 7, 2013·BMC Surgery·Alessandro CappellaniMassimiliano Berretta
Apr 21, 2012·The Breast : Official Journal of the European Society of Mastology·Adriana J Maaskant-BraatGrard A Nieuwenhuijzen
Aug 9, 2015·Clinical Breast Cancer·Ingrid van den HovenRudi M H Roumen
Jul 30, 2016·Archives of Pathology & Laboratory Medicine·Aoife Maguire, Edi Brogi
Sep 2, 2014·Journal of Surgical Oncology·Max VaynrubLawrence R Menendez

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