PMID: 9523850Apr 2, 1998Paper

Value of methylprednisolone in prevention of the arthralgia-myalgia syndrome associated with the total dose infusion of iron dextran: a double blind randomized trial

The Journal of Laboratory and Clinical Medicine
Michael AuerbachHarold Ballard

Abstract

The safety and efficacy of total dose infusion (TDI) of iron dextran has been well documented. In 40% of treated patients, an arthralgia-myalgia syndrome develops. The purpose of this randomized, double-blind, prospective study was to investigate whether intravenous (i.v.) administration of methylprednisolone (MP) prevents this complication. Sixty-five patients, 34 women and 31 men, ages 36 to 80 years, received either normal saline before and after TDI (group 1), 125 mg i.v. MP before and saline after TDI (group 2), or 125 mg i.v. MP before and after TDI (group 3). Patients were observed for 72 hours and reactions were recorded and graded according to severity. Fifty-eight percent of group 1 patients, 33% of group 2, and 26% of group 3 had reactions to TDI. The severity of reactions (minimal, mild, and moderate, respectively) was as follows: group 1--6, 6, and 2; group 2--1, 5, and 0; group 3--5, 1, and 0. Data were analyzed by the two-sided Fisher's exact test using 95% confidence intervals with the approximation of Woolf. These data demonstrate that administration of MP before and after TDI reduces the frequency and severity of the arthralgia-myalgia syndrome. We conclude that 125 mg i.v. MP should be given routinely before ...Continue Reading

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Citations

Apr 20, 2002·Journal of Pediatric Gastroenterology and Nutrition·Petar MamulaRobert N Baldassano
Apr 12, 2007·Journal of Clinical Gastroenterology·Ronald ConchaJamie S Barkin
Jan 18, 2011·Hematology·Michael Auerbach, Harold Ballard
Sep 30, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Paolo FerrariJohn K Olynyk
Jan 1, 2011·Revista brasileira de hematologia e hemoterapia·Rodolfo Delfini Cançado, Manuel Muñoz
Jan 15, 2014·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Fiona E Ralley
Jul 16, 2014·Immunology and Allergy Clinics of North America·Andreas J Bircher, Michael Auerbach
Apr 18, 2013·Best Practice & Research. Clinical Anaesthesiology·Michael AuerbachAryeh Shander
Sep 27, 2015·American Journal of Hematology·Michael Auerbach, John W Adamson
Jul 18, 2008·Supportive Cancer Therapy·David H Henry
Feb 13, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·David B Van WyckGeorge Aronoff
Jan 6, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G R BailieN A Mason
May 8, 2007·Lancet·Michael AuerbachJohn Glaspy
Aug 13, 2015·British Journal of Pharmacology·J SzebeniJ Folkersen
Feb 15, 2008·American Journal of Hematology·Michael AuerbachHarold Ballard
Oct 4, 2005·Advances in Chronic Kidney Disease·Larry A Greenbaum
Oct 22, 2008·American Journal of Obstetrics and Gynecology·Melvin H SeidRalph Rogers
Mar 2, 2005·Best Practice & Research. Clinical Haematology·James D Cook
Oct 6, 2005·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Dion Smyth, Sabine Zumbrink
Nov 11, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Manish Saha, Michael Allon
Mar 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael AuerbachJeevindra Rana
Dec 31, 2016·Blood·Maureen M Achebe, Anat Gafter-Gvili
Jan 10, 2014·Current Opinion in Nephrology and Hypertension·Derek S Larson, Daniel W Coyne
Mar 14, 2008·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Stacy S ShordSandra Cuellar
Nov 25, 2003·Hematology·Ernest BeutlerJames D Cook
Jan 25, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Esther Helen Steveling-KleinKathrin Scherer Hofmeier
Feb 14, 2021·American Journal of Hematology·Michael AuerbachThomas G DeLoughery
Mar 7, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation

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