PMID: 6984110Nov 1, 1982Paper

Value of monoamine metabolite determinations in CSF as an index of their concentrations in rat brain following various pharmacological manipulations

Journal of Pharmacological Methods
M G PalfreymanJ Wagner

Abstract

Using reversed-phase high performance liquid chromatography with electrochemical detection it is possible to measure concomitantly the concentration of several monoamines, their metabolites and aminoacid precursors in 100 microliters of rat cerebrospinal fluid. To study the quantitative relationship between CSF and brain, alterations in brain monoamines and monoamine metabolites were effected by treatment with L-DOPA or L-5HTP administered with or without concomitant inhibition of extracerebral aromatic amino acid decarboxylase and by treatment with alpha-monofluoromethyldopa, probenecid, haloperidol, or probenecid plus haloperidol. The concentrations of the monoamine metabolites, 5-hydroxyindoleacetic acid, 3,4-dihydroxyphenylacetic acid, and homovanillic acid as well as of the L-DOPA metabolite, 3-methoxy-4-hydroxyphenylalanine in the cerebrospinal fluid were linearly correlated with the concentrations of these metabolites in the brain. However, these correlations need to be interpreted cautiously, since the slopes of the individual regression lines obtained after different pharmacological treatments differed significantly.

References

May 11, 1979·Brain Research·P BöhlenM G Palfreyman
Jun 23, 1978·Brain Research·M L Aizenstein, J Korf
Dec 5, 1975·Brain Research·D C JimersonF K Goodwin
Jan 1, 1973·The American Journal of Psychiatry·F K GoodwinE K Gordon
Jan 1, 1970·Brain : a Journal of Neurology·A T MoirH C Guldberg
Sep 1, 1968·Journal of Neurochemistry·D EcclestonD P O'Mahoney
Jun 15, 1970·Life Sciences. Pt. 1: Physiology and Pharmacology·M B Bowers
Mar 19, 1971·Brain Research·G BartholiniA Pletscher
Dec 1, 1980·British Journal of Pharmacology·P BeyM Zraïka
Aug 1, 1962·British Journal of Pharmacology and Chemotherapy·G W ASHCROFT, D F SHARMAN

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Citations

May 4, 1984·European Journal of Pharmacology·G S SarnaG Curzon
Mar 28, 2012·Brain : a Journal of Neurology·David S GoldsteinYehonatan Sharabi
Jan 1, 1983·Journal of Neural Transmission·J L ElghoziK H Le Quan-Bui
Jul 6, 2010·Animal Science Journal = Nihon Chikusan Gakkaihō·Etsuko KasuyaMadoka Sutoh
Sep 1, 1987·Pharmacology & Toxicology·H Scheinin, M Scheinin
Jul 31, 2016·Parkinsonism & Related Disorders·David S GoldsteinYehonatan Sharabi
Mar 10, 2001·Microscopy Research and Technique·J M Pérez-FígaresE M Rodríguez
Apr 1, 1985·Journal of Neurochemistry·C Duval, E Mignot
Feb 1, 1996·Cephalalgia : an International Journal of Headache·J CastilloM Noya
Feb 21, 2018·Frontiers in Neural Circuits·Andreas BjorefeldtEric Hanse

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