Value of noninvasive hemodynamics to achieve blood pressure control in hypertensive subjects

Hypertension
Ronald D SmithConsideration of Noninvasive Hemodynamic Monitoring to Target Reduction of Blood Pressure Levels Study Group

Abstract

Abnormal hemodynamics play a central role in the development and perpetuation of high blood pressure. We hypothesized that hypertension therapy guided by noninvasive hemodynamics with impedance cardiography could aid primary care physicians in reducing blood pressure more effectively. Uncontrolled hypertensive patients on 1 to 3 medications were randomized by 3:2 ratio to either a standard arm or hemodynamic arm that used impedance cardiography (BioZ, CardioDynamics). Each patient completed 5 study visits with a 2-week washout period followed by 3 months of treatment. A total of 164 patients from 11 centers completed the study, 95 in the standard arm and 69 in the hemodynamic arm. At baseline and after washout, there were no differences between arms in number of medications or demographic, blood pressure, or hemodynamic characteristics. Systolic blood pressure reductions in the hemodynamic arm were greater from baseline (19 mm Hg versus 11 mm Hg; P<0.01) and after washout (25 mm Hg versus 19 mm Hg; P<0.05). Diastolic blood pressure reductions were also greater in the hemodynamic arm from baseline (12 mm Hg versus 5 mm Hg; P<0.001) and after washout (17 mm Hg versus 10 mm Hg; P<0.001). The hemodynamic arm achieved goal blood pre...Continue Reading

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References

Dec 1, 1978·Circulation Research·C M Ferrario, I H Page
Aug 1, 1987·Annals of Internal Medicine·F H MesserliC Amodeo
May 23, 2002·Hypertension·Sandra J TalerJo Ellen Augustine
Dec 20, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatm
Jun 11, 2003·Chest·Joseph M Van De WaterMartin L Dalton
Nov 15, 2003·Lancet·Fiona Turnbull, UNKNOWN Blood Pressure Lowering Treatment Trialists' Collaboration
Dec 23, 2003·Journal of General Internal Medicine·Paul A Heidenreich
Jan 1, 2004·American Journal of Hypertension·Alan L HinderliterAndrew Sherwood
Feb 12, 2004·Congestive Heart Failure·Donald L SharmanJillian P Rutherford
Feb 22, 2005·The Journal of Clinical Hypertension·Hardeep Singh, Michael L Johnson
Mar 9, 2005·American Journal of Hypertension·Abdelhammed I AbdelhammedCarlos M Ferrario
Mar 9, 2005·American Journal of Hypertension·José AlfieGabriel Waisman
Mar 16, 2005·Journal of the American College of Cardiology·Bryan Williams
May 11, 2005·Cardiovascular Drugs and Therapy·Anna MitchellJens Nürnberger

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Citations

Aug 30, 2008·JAMA : the Journal of the American Medical Association·Daniel I FeigRichard J Johnson
Aug 18, 2006·Current Heart Failure Reports·David J Wang, Stephen S Gottlieb
Apr 6, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Paweł KrzesińskiJarosław Józef Kowal
Jan 10, 2014·Obstetrics and Gynecology·Rachael MorrisJames N Martin
Jun 5, 2007·Current Cardiology Reports·David J Wang, Stephen S Gottlieb
Sep 9, 2010·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Marc R ParrishJames N Martin
Jul 3, 2015·Journal of Human Hypertension·P KrzesińskiK Piotrowicz
Jun 27, 2009·Clinics in Geriatric Medicine·Mohammed A Rafey
Apr 17, 2007·International Journal of Cardiology·J M Cruickshank
Nov 7, 2006·The American Heart Hospital Journal·Carlos M FerrarioUNKNOWN CONTROL Trial Investigators
Jan 15, 2013·Upsala Journal of Medical Sciences·Zhao XiajuanHong Zhen
Apr 14, 2016·Current Hypertension Reports·Stewart Siu-Wa ChanT H Rainer
Mar 9, 2005·American Journal of Hypertension·Marcellus Francis L RamirezEduardo Vicente S Caguioa
Oct 21, 2016·Clinical and Experimental Pharmacology & Physiology·Marcelo A RadaGabriel D Waisman
Oct 21, 2016·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D StottN A Kametas
Nov 30, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Branko BraamS Susan Hedayati
Nov 2, 2016·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D StottN A Kametas
Nov 28, 2013·Therapeutic Advances in Cardiovascular Disease·Carlos M FerrarioRonald D Smith
Jan 7, 2009·Therapeutic Advances in Cardiovascular Disease·Carlos M FerrarioDaniel L Wise
Feb 1, 2008·European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology·Judith A McFetridge-DurdleB Tucker
Jan 7, 2009·Therapeutic Advances in Cardiovascular Disease·Ronald D Smith, Pavel J Levy
Apr 2, 2009·The Annals of Pharmacotherapy·William L BakerCraig I Coleman
Apr 11, 2018·Current Hypertension Reports·B E Smith, V M Madigan
Dec 5, 2015·Therapeutic Advances in Cardiovascular Disease·Paweł KrzesińskiAndrzej Skrobowski
Nov 28, 2017·Clinical and Experimental Hypertension : CHE·Rodrigo Nazário LeãoRoberto Palma Reis
Jan 1, 2010·Therapeutic Advances in Cardiovascular Disease·Carlos M FerrarioCeline Peters
Jul 17, 2018·Journal of the American Heart Association·Kelsey McLaughlinJohn C Kingdom
Oct 4, 2006·Hypertension·Samuel J Mann
Sep 26, 2012·Hypertension·Beth Soletsky, Daniel I Feig
Oct 6, 2010·Hypertension·John M FlackUNKNOWN International Society on Hypertension in Blacks
Feb 14, 2018·Hypertension·Kelsey McLaughlinJohn D Parker
Feb 16, 2013·Journal of Hypertension·Antti J TikkakoskiIlkka H Pörsti
Jun 15, 2017·Clinical and Experimental Hypertension : CHE·Ali YeşiltepeAli Ihsan Gunal
Oct 21, 2015·Journal of Hypertension·Fadl Elmula M Fadl ElmulaUNKNOWN BEtter control of blood pressure in hypertensive pAtients monitored Using the HOTMAN sYstem (BEAUTY) Study Investigators
Aug 25, 2017·Current Hypertension Reports·Christoph Lees, Enrico Ferrazzi
Mar 27, 2020·Journal of the American Geriatrics Society·Shiwani MahajanHarlan M Krumholz
Aug 17, 2012·Journal of Hypertension·Jens Jordan, Jens Tank
Apr 26, 2018·BMC Obesity·Catarina Santos, Pedro Marques da Silva

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