Value of O-(2-[18F]fluoroethyl)- L-tyrosine PET for the diagnosis of recurrent glioma

European Journal of Nuclear Medicine and Molecular Imaging
G PöpperlK Tatsch

Abstract

The prognosis of patients with recurrent gliomas depends on reliable and early diagnosis of tumour recurrence after initial therapy. In this context, magnetic resonance imaging (MRI) and computed tomography (CT) often fail to differentiate between radiation- and tumour-induced contrast enhancement. Furthermore, absence of contrast enhancement, or even of 18F-fluorodeoxyglucose uptake in PET, does not exclude recurrence. The aim of this study was to establish the diagnostic value of O-(2-[18F]fluoroethyl)- L-tyrosine (FET) PET in recurrent gliomas. Fifty-three patients with glioma (primary grading: 27=WHO grade IV, 16=grade III, 9=grade II, 1=grade I) and clinically suspected recurrence underwent FET PET scans 4-180 months after different treatment modalities. For semiquantitative evaluation, maximal SUV (SUVmax) and mean SUV within 80% and 70% isocontour thresholds (SUV80/SUV70) were evaluated and the respective ratios to the background (BG) were calculated. PET results were correlated with MRI/CT, clinical follow-up or biopsy findings. All patients presented with FET uptake, of varying intensity, in the area of the primary tumour after initial therapy. In the 42 patients with confirmed recurrence, there was additional distinct...Continue Reading

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Citations

Jul 30, 2010·Der Nervenarzt·A-L Grosu, R-D Kortmann
Mar 16, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Nicolas SpaethAlfred Buck
Mar 22, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Gabriele PöpperlKlaus Tatsch
May 20, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Dirk HellwigSamuel Samnick
Sep 4, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Gabriele PöpperlKlaus Tatsch
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