PMID: 7025071Aug 1, 1981Paper

Value of platelet sensitivity to antiaggregatory prostaglandins (PGI2, PGE1, PGD2) in 50 patients with myocardial infarction at young age

Prostaglandins and Medicine
H SinzingerP Probst

Abstract

Based upon earlier findings of our group that not only the synthesis of antiaggregatory prostaglandins by the vessel wall is altered in atherosclerotic vascular tissue of patients, but also the sensitivity of their platelets to these prostaglandins is changed, we examined a well defined group of 50 patients with myocardial infarction before the age of 40 years. In all patients the coronary heart disease was verified by angiography. The sensitivity of the platelets was examined in relation ot the smoking habit, the type and presence of hyperlipoproteinemia, one, two and three vessel disease and familial history. Except for hyperlipoproteinemia and smoking, all the patients were free of any additional risk factor. It is demonstrated that the platelet sensitivity to the antiaggregatory prostaglandins is significantly diminished in hyperlipoproteinemics in comparison to a control group.

References

Feb 15, 1979·The New England Journal of Medicine·M SchydlowerP H Patterson
Feb 1, 1979·The Journal of Clinical Investigation·A M SieglD Ahern

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Citations

Mar 1, 1991·American Journal of Hematology·H SinzingerJ O'Grady
Aug 1, 1996·Clinical Cardiology·J A FournierA González-Barrero
Oct 1, 1985·Prostaglandins, Leukotrienes, and Medicine·S D KristensenJ Dyerberg
Mar 1, 1985·Prostaglandins, Leukotrienes, and Medicine·H SinzingerB A Peskar
Sep 1, 1986·Prostaglandins, Leukotrienes, and Medicine·H SinzingerB A Peskar
Aug 1, 1987·Prostaglandins, Leukotrienes, and Medicine·E Strobl-JägerB A Peskar
Mar 1, 1996·The Journal of Emergency Medicine·M G KanitzM Mott
Aug 14, 1982·Lancet·V SeagroattC H Cameron
Jul 4, 2001·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·N J WalkerJ E Hollander
Oct 30, 2012·Journal of Lipid Research·Alison M StrackAyesha Sitlani
Dec 1, 1986·The American Journal of Cardiology·B SharmaJ A Franciosa
Jul 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·I VirgoliniH Sinzinger
Feb 1, 1981·Prostaglandins and Medicine·O BurghuberP Haber
Jan 1, 1985·Medicinal Research Reviews·R C NickolsonH Vorbrüggen
Jan 1, 1983·Annals of the New York Academy of Sciences·J C de la Torre
Jan 1, 1985·Acta Medica Scandinavica. Supplementum·H Vapaatalo
Jan 1, 1987·Pharmacotherapy·R E Nitz, V B Fiedler
Jan 1, 1983·Acta Medica Scandinavica·A NordøyR A Lenner
Nov 1, 1987·Pharmacological Research Communications·D Oliva, S Nicosia

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