PMID: 488753Jul 1, 1979Paper

Value of sigmoidoscopy and biopsy in detection of carcinoma and premalignant change in ulcerative colitis

Gut
R H Riddell, B C Morson

Abstract

Of 111 carcinomas developing in 73 patients with ulcerative colitis, 46 (41.5%) arose in the rectum where they are directly accessible to sigmoidoscopy. Fifty-eight per cent of single carcinomas developed in the rectum. The extent and frequency of rectal dysplasia was assessed by examining slides of rectal mucosa with an eyepiece micrometer. Slides from 46 patients with carcinoma and 22 patients with dysplasia but no carcinoma in whom proctectomy or proctocolectomy had been carried out were examined by this method. Thirteen of 15 patients with carcinoma of the colon (87%) and 21/22 patients (95%) with large bowel dysplasia showed evidence only of rectal dysplasia. However, there was marked variability in the proportion of dysplastic rectal mucosa even in those patients with rectal carcinoma, while in some patients dysplasia was limited to a small focus. Because of the possibility of false negative biopsies due to sampling error, multiple biopsies should be taken to detect dysplasia. Their state should be recorded and deliberately varied at subsequent visits. Careful sigmoidoscopy and multiple biopsies in this study had potential value as an aid in the detection of 85-90% of all carcinomas. In practice the figure would almost ce...Continue Reading

References

Jan 1, 1976·Current Topics in Pathology. Ergebnisse Der Pathologie·R H Riddell
Dec 16, 1976·JAMA : the Journal of the American Medical Association·T D CrowsonJ B Gathright
Jun 1, 1974·Lancet·J E Lennard-JonesC B Williams
Jan 1, 1972·Scandinavian Journal of Gastroenterology·L HulténC Ahrén
Apr 1, 1974·Gut·H E MyrvoldC Ahrén
Jan 1, 1971·Major Problems in Pathology·N K Mottet

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Citations

Oct 1, 1992·Diseases of the Colon and Rectum·B A TaylorA R Zinsmeister
Apr 1, 1982·The New England Journal of Medicine·J B Kirsner, R G Shorter
Dec 1, 1990·Gut·B I KorelitzS C Sommers
Jan 1, 1985·Journal of Clinical Pathology·D C AllenP C Pyper
Apr 1, 1995·Journal of Gastroenterology·K MakiyamaT Nakagoe
Jan 11, 2014·BMC Gastroenterology·Mariann Friis-OttessenOle Petter F Clausen
May 1, 1987·Scandinavian Journal of Gastroenterology·B BørkjeE Schrumpf
Jan 1, 1980·Scandinavian Journal of Gastroenterology·S GranqvistP Sundelin
May 1, 1984·American Journal of Surgery·R C HarrisonD A Owen
Mar 1, 1997·Baillière's Clinical Gastroenterology·F A Macrae, P S Bhathal
Oct 29, 2000·The American Journal of Gastroenterology·J A Eaden, J F Mayberry
Jan 1, 1982·International Journal of Health Services : Planning, Administration, Evaluation·D Sanders
Sep 1, 1987·Histopathology·C A CuvelierH J Roels
Jul 26, 1980·The Medical Journal of Australia·G L BarnesL S Naidoo
Jul 16, 1983·Lancet·J E Lennard-JonesC B Williams
Nov 1, 1982·Human Pathology·H Goldman, D A Antonioli

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